Stock listing
NASDAQ:SPRB Spruce Biosciences, Inc. Stock
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Share price · NASDAQ:SPRB
$46.39 USD -0.43 (-0.9%)
Close on Oct 30, 2026
- Day range
- $44.69 – $46.62 USDOct 30, 2026
- Volume
- 65,958 sharesOct 30, 2026
- Market cap
- $133.3M USDAt the close on Oct 30, 2026 · price × 2.87M shares outstanding
- 52-week range
- $38.06 – $129.00 USDLowest and highest trades, Oct 31, 2025 – Oct 30, 2026
- Traded on an average day
- $4.09M USDMedian day 74,350 shares · last 3 months, Jul 30, 2026 – Oct 30, 2026
Prices by listing
| Listing | Last | Change | Volume | Open | High | Low | Previous close | Price from |
|---|---|---|---|---|---|---|---|---|
| NASDAQ:SPRB · Home | $46.39 USD | -0.43 (-0.9%) | 65,958 | $46.11 | $46.62 | $44.69 | $46.82 | Close on Oct 30, 2026 |
Daily closes
Last 3 months, Jul 30, 2026 – Oct 30, 2026 · NASDAQ:SPRB · USD, adjusted for splits
| Day | Close | Change | % | Open | High | Low | Volume |
|---|---|---|---|---|---|---|---|
| $46.39 | -0.43 | -0.9% | $46.11 | $46.62 | $44.69 | 65,958 | |
| $46.82 | -0.17 | -0.4% | $47.50 | $49.85 | $46.51 | 104,183 | |
| $46.99 | +1.34 | +2.9% | $45.65 | $47.25 | $45.65 | 58,802 | |
| $45.65 | +1.66 | +3.8% | $44.54 | $46.90 | $44.01 | 91,553 | |
| $43.99 | -1.16 | -2.6% | $45.47 | $45.47 | $43.62 | 66,476 | |
| $45.15 | -0.85 | -1.8% | $45.80 | $46.10 | $43.34 | 73,800 | |
| $46.00 | +3.27 | +7.7% | $42.58 | $46.25 | $42.51 | 126,500 | |
| $42.73 | +1.50 | +3.6% | $41.00 | $42.73 | $40.82 | 61,500 | |
| $41.23 | +0.83 | +2.1% | $40.57 | $42.65 | $40.40 | 52,500 | |
| $40.40 | +0.75 | +1.9% | $39.97 | $41.00 | $39.25 | 57,100 | |
| $39.65 | -1.82 | -4.4% | $41.53 | $41.84 | $39.21 | 88,400 | |
| $41.47 | +2.49 | +6.4% | $39.00 | $41.88 | $39.00 | 63,800 | |
| $38.98 | -1.37 | -3.4% | $40.00 | $41.44 | $38.06 | 112,700 | |
| $40.35 | -2.52 | -5.9% | $42.80 | $42.91 | $40.19 | 110,600 | |
| $42.87 | -1.18 | -2.7% | $44.09 | $44.94 | $42.55 | 74,900 | |
| $44.05 | -1.49 | -3.3% | $44.84 | $45.04 | $42.80 | 83,800 | |
| $45.54 | +1.14 | +2.6% | $43.50 | $45.65 | $43.34 | 50,800 | |
| $44.40 | +1.615 | +3.8% | $42.56 | $45.40 | $42.37 | 59,700 | |
| $42.79 | -2.635 | -5.8% | $45.60 | $46.72 | $42.50 | 101,900 | |
| $45.42 | -0.29 | -0.6% | $45.51 | $46.80 | $43.83 | 65,100 | |
| $45.71 | +0.94 | +2.1% | $46.58 | $47.73 | $44.13 | 77,200 | |
| $44.77 | -3.81 | -7.8% | $48.15 | $49.20 | $44.47 | 79,600 | |
| $48.58 | +1.31 | +2.8% | $47.78 | $49.95 | $47.76 | 61,300 | |
| $47.27 | -0.24 | -0.5% | $47.55 | $48.00 | $46.55 | 84,200 | |
| $47.51 | -1.21 | -2.5% | $48.28 | $48.99 | $47.01 | 42,400 | |
| $48.72 | -0.30 | -0.6% | $49.22 | $49.31 | $47.54 | 37,200 | |
| $49.02 | -0.395 | -0.8% | $49.01 | $49.50 | $47.58 | 85,800 | |
| $49.42 | -0.575 | -1.2% | $50.50 | $50.74 | $45.01 | 174,800 | |
| $49.99 | -3.71 | -6.9% | $54.05 | $54.98 | $49.23 | 140,700 | |
| $53.70 | +0.65 | +1.2% | $53.84 | $55.06 | $53.07 | 96,500 | |
| $53.05 | -0.81 | -1.5% | $53.04 | $53.86 | $51.80 | 99,700 | |
| $53.86 | -0.30 | -0.6% | $56.22 | $57.11 | $53.28 | 135,300 | |
| $54.16 | -1.005 | -1.8% | $55.01 | $56.27 | $53.26 | 96,600 | |
| $55.17 | -1.685 | -3.0% | $55.99 | $56.36 | $54.51 | 105,500 | |
| $56.85 | +3.15 | +5.9% | $53.28 | $57.55 | $52.66 | 102,600 | |
| $53.70 | -0.65 | -1.2% | $54.78 | $56.08 | $53.09 | 88,500 | |
| $54.35 | -1.39 | -2.5% | $55.61 | $57.50 | $54.03 | 113,000 | |
| $55.74 | -3.35 | -5.7% | $58.52 | $59.01 | $55.70 | 91,900 | |
| $59.09 | +1.16 | +2.0% | $57.39 | $60.51 | $56.60 | 193,000 | |
| $57.93 | +0.22 | +0.4% | $57.37 | $58.19 | $56.57 | 103,900 | |
| $57.71 | -1.96 | -3.3% | $59.76 | $60.32 | $57.30 | 113,500 | |
| $59.67 | +4.07 | +7.3% | $56.52 | $60.13 | $56.52 | 268,100 | |
| $55.60 | -3.37 | -5.7% | $58.01 | $58.05 | $55.34 | 58,100 | |
| $58.97 | -1.81 | -3.0% | $60.54 | $60.90 | $57.58 | 44,900 | |
| $60.78 | -2.52 | -4.0% | $62.12 | $62.98 | $59.90 | 40,000 | |
| $63.30 | +1.82 | +3.0% | $62.00 | $63.56 | $60.55 | 80,300 | |
| $61.48 | -1.92 | -3.0% | $64.50 | $64.50 | $60.46 | 91,800 | |
| $63.40 | +4.75 | +8.1% | $58.82 | $64.15 | $58.00 | 147,298 | |
| $58.65 | +7.07 | +13.7% | $53.04 | $58.92 | $51.16 | 138,812 | |
| $51.58 | -0.405 | -0.8% | $52.48 | $53.00 | $49.03 | 62,300 | |
| $51.99 | -0.975 | -1.8% | $52.83 | $52.89 | $50.50 | 21,600 | |
| $52.96 | +0.115 | +0.2% | $54.18 | $54.93 | $52.02 | 88,300 | |
| $52.85 | -0.075 | -0.1% | $51.31 | $53.95 | $50.80 | 71,400 | |
| $52.92 | +0.28 | +0.5% | $51.57 | $53.60 | $48.92 | 34,800 | |
| $52.64 | +2.87 | +5.8% | $50.14 | $52.64 | $48.55 | 42,300 | |
| $49.77 | +2.70 | +5.7% | $47.33 | $51.25 | $47.31 | 50,700 | |
| $47.07 | +0.66 | +1.4% | $46.95 | $49.00 | $46.26 | 26,200 | |
| $46.41 | +0.21 | +0.5% | $46.41 | $47.45 | $46.11 | 24,251 | |
| $46.20 | -0.67 | -1.4% | $46.69 | $46.69 | $45.01 | 35,631 | |
| $46.87 | +0.45 | +1.0% | $47.00 | $47.43 | $45.88 | 34,000 | |
| $46.42 | -0.19 | -0.4% | $46.38 | $47.41 | $45.24 | 39,500 | |
| $46.61 | +0.35 | +0.8% | $46.80 | $47.13 | $45.35 | 27,900 | |
| $46.26 | +3.12 | +7.2% | $44.50 | $46.34 | $43.68 | 63,300 | |
| $43.14 | +0.31 | +0.7% | $42.02 | $44.38 | $41.46 | 48,300 | |
| $42.83 | -0.54 | -1.2% | $43.06 | $43.30 | $42.00 | 23,400 | |
| $43.37 | +1.92 | +4.6% | $41.99 | $43.49 | $41.99 | 59,200 |
- Ticker
- NASDAQ:SPRB
- Asset type
- Stock
- Sector
- Health care
- Industry
- Biotechnology
- Exchange
- NASDAQ
- Currency
- USD
What changed lately
Latest news release · Oct 15, 2026
Spruce Biosciences to Participate in the Craig-Hallum Biotech Catalyst Conference
Latest deck · Aug 12, 2026
Investor Presentation (August 2026)
Investor deck · 22 slides
Latest news
Spruce Biosciences to Participate in the Craig-Hallum Biotech Catalyst Conference
Oct 15, 2026
Closed $39.65 (-4.4%) on Oct 16, 2026
Spruce Biosciences Announces Presentation of MPS IIIB Natural History Data at the 55th Child Neurology Society Annual Meeting
Oct 8, 2026
Closed $44.05 (-3.3%) on Oct 9, 2026
Spruce Biosciences to Participate in the H.C. Wainwright 28th Annual Global Investment Conference
Sep 8, 2026
Closed $55.74 (-5.7%) on Sep 9, 2026
Spruce Biosciences Announces Launch of MPS3BStudy.com
Aug 26, 2026
Closed $61.48 (-3.0%) on Aug 26, 2026
Spruce Biosciences Announces Positive Pre-BLA Meetings with FDA and Confirms BLA Submission for TA-ERT on Track for Q4 2026
Aug 24, 2026
Closed $58.65 (+13.7%) on Aug 24, 2026
Cure Sanfilippo Foundation and National MPS Society Make $5.5 Million Strategic Investment in Spruce Biosciences
Aug 12, 2026
Closed $47.07 (+1.4%) on Aug 12, 2026
Spruce Biosciences Appoints Jessica Cohen Pfeffer, M.D., as Vice President, Clinical Development
Aug 3, 2026
Closed $43.14 (+0.7%) on Aug 3, 2026
Spruce Biosciences Appoints Adrian Quartel, M.D., FFPM, as Chief Medical Officer
Jul 27, 2026
Closed $41.99 (-2.5%) on Jul 27, 2026
Spruce Biosciences to Participate in the B. Riley Securities 2026 Mind, Muscle & Vision Healthcare Summit
Jul 8, 2026
Closed $51.74 (+3.9%) on Jul 9, 2026
Spruce Biosciences Joins the Russell 3000® Index
Jun 29, 2026
Closed $55.88 (+1.4%) on Jun 29, 2026
Financings
Strategic investment
Aug 12, 2026
Announced: US$5.5M
Buyers: Cure Sanfilippo Foundation (part of a combined $5.5 million strategic investment); National MPS Society (part of a combined $5.5 million strategic investment)
Use of proceeds: Partially fund the TA-ERT Expanded Access Program to broaden patient access to TA-ERT for Sanfilippo Syndrome Type B
Decks
Investor Presentation (August 2026)
Investor deck · 22 slides · Aug 12, 2026
Corporate Update (April 2025)
Corporate update · 15 slides · Apr 15, 2025
Baird 2021 Global Healthcare Conference
Conference · 17 slides · Sep 15, 2021
Investor Day (August 2021)
Investor day · 68 slides · Aug 25, 2021
Spruce Biosciences, Inc. on 6ix
- Sector
- Health care
- Industry
- Biotechnology
- News releases
- 29 in the last 12 months · 83 in all · newest Oct 15, 2026 · oldest 2020
- Decks
- 4 decks · latest Aug 12, 2026
Where Spruce Biosciences, Inc. is listed
| Listing | Exchange | Country | Currency |
|---|---|---|---|
| NASDAQ:SPRB · Home listing · This page | NASDAQ | United States | USD |
| BOATS:SPRB | BOATS | United States | USD |
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