Ercros, S.a. · BME:ECR
Ercros — Corporate Update (2023)
25 slides from Ercros's corporate update, 2023
Slide 1: Aranjuez factory
Aranjuez factory
Slide 2: Key data. Year 2022
Key data. Year 2022 47 % 143 M€ 1989 1,348 10 998 M€ Export (>90 Adjusted Foundation Workforce Factories Sales countries) ebitda 3 Divisions Chlorine Pharmaceuticals derivatives Intermediate chemicals 2
Slide 3: Factories
Factories Sabiñánigo Monzón Flix Cerdanyola Tarragona industrial Tortosa complex Aranjuez Almussafes Tarragona industrial complex • Vila-seca I • Vila-seca II • Tarragona Chlorine derivatives Intermediate chemicals Pharmaceuticals 3
Slide 4: Key data from the Aranjuez factory. Year 2022
Key data from the Aranjuez factory. Year 2022 USA,UE y 1949 2018 93% 65 M€ MENA* Foundation Workforce Exports Sales Markets *MENA: Middle East and North Africa. 4
Slide 5: Factory location
Factory location Paseo del Deleite 5
Slide 6: Business model
Business model ▪ The activity of the Aranjuez factory focuses on the production of raw materials and API (Active Pharmaceutical Ingredients), mainly antibiotics. ▪ The factory also specialises in the production of active ingredients and intermediates for third parties, tailor- made for customers. 6
Slide 7: Products, applications and market share. Year 2022
Products, applications and market share. Year 2022 Products Applications Ranking by market share Azithromycin Respiratory infections Spain Europe World Erythromycins 1st 1st - Clarithromycin Respiratory infections Fosfomycins 1st 2nd 3rd Erythromycin and salts Respiratory infections Fusidic acid - 2
Slide 8: Production and facilities
Production and facilities 43,000 kg/year Production capacity 1 1 1 Multifunctional 2 Sterile Fermentation synthesis plant Intermediate production and plant with 3 products plants mixing plant production line 8
Slide 9: Scheme of the biological production process
Scheme of the biological production process Raw materials Intermediate processes Final products • Fusidic acid Fusidic • Sodium fusidate Derivatives Sugar raw • Diethanolamine fusidate Fermentation Extraction Oil • Ethylsuccinate Derivatives • Stearate Vegetable Erythromycin • Stolate proteins base
Slide 10: Scheme of the chemical synthesis production process
Scheme of the chemical synthesis production process Raw materials Intermediate process Final products Fosfomycin calcium Phosphorus trichloride Fosfomycin trometamol Propardylic Sterile alcohol fosfomycin Fosfomycin sodium sodium (injectable) Acid Fosfomycin olefinic PEA salt 10
Slide 11: Markets and sectors. Year 2022
Markets and sectors. Year 2022 Where do we sell? Spain Rest of the world Rest of the EU Rest of OECD 11
Slide 12: Erythromycin
Erythromycin Applications Varieties ▪ Erythromycin is a broad-spectrum ▪ Salts: ethylsuccinamate, estolate, bacterial antibiotic. stearate, propionate and thiocyanate. ▪ Especially indicated in respiratory and ▪ Derivatives: azithromycin and skin conditions. clarithromycin. Markets ▪ More than 70% o
Slide 13: Clarithromycin
Clarithromycin Applications ▪ Antibiotic indicated for the treatment of skin and respiratory tract infections, such as pharyngitis, tonsillitis, sinusitis, chronic bronchitis or bacterial pneumonia, among others. ▪ One of its most common uses is the treatment of gastric ulcers caused by helicobacter
Slide 14: Fosfomycin
Fosfomycin Applications ▪ Fosfomycin is a broad-spectrum antibiotic. ▪ It is used specifically to combat hospital infections and urinary and genital tracts. Markets Varieties ▪ Around 90% of production is ▪ Sodium exported, mainly to EU countries, ▪ Calcic Japan and Mexico. ▪ Trometamol 14
Slide 15: Fusidic acid and salts
Fusidic acid and salts Applications ▪ Fusidic acid is an antibiotic for the treatment of severe skin and eye infections. ▪ Sodium fusidate is a salt derived from fusidic acid, with the same pharmacological properties, but whose own characteristics allow its application in different presentations, su
Slide 16: Famotidine
Famotidine Applications Markets ▪ Powerful antiulcer. ▪ 100% of famotidine is ▪ Indicated for the exported to the US. treatment of ▪ Consolidated product in gastrointestinal ulcers the North American and other digestive market, with high added disorders. value. ▪ It is also given to surgical patient
Slide 17: Vancomycin and gentamycin
Vancomycin and gentamycin Vancomycin hydrochloride ▪ Effective antibiotic in the treatment of infections caused by resistant gram- positive bacteria. ▪ Effective in serious infections caused by staphylococci. ▪ Indicated for the treatment of meningitis, peritonitis, sepsis, colitis, etc. Gentamycin
Slide 18: Other products
Other products Venlafaxine Amlodipine besilate Terbinafine ▪ Antidepressant that ▪ Calcium channel blocker, ▪ Specific antifungal in works by inhibiting the which acts as an dermatological reuptake of serotonin antihypertensive and infections. and norepinephrine. antianginal. Markets Production capa
Slide 19: The 3D Plan in Aranjuez
The 3D Plan in Aranjuez ▪ The 3D Plan is the strategic plan launched by Ercros, which pursues its transformation into a sustainable company and is based on three dimensions: diversification, digitalisation and decarbonisation or the fight against climate change. ▪ Main activities included in the Ara
Slide 20: R+D
R+D ▪ Development of manufacturing processes for new active ingredients, both through chemical synthesis and fermentation. ▪ Maintenance and improvement of new or existing strains. ▪ Optimization of production processes to improve productivity and reduce environmental and/or safety risks for people
Slide 21: Accreditations
Accreditations ▪ Prevention management system according to ISO 45001 standard. ▪ Quality management system according to ISO 9001 standard. ▪ Environmental management system according to ISO 14001 standard. ▪ Verification of greenhouse gas (GHG) emissions according to ISO 14064 standard. ▪ Verificati
Slide 22: Programs and ratings
Programs and ratings ▪ Responsible Care: Program of good practices in sustainability by the chemical sector. ▪ Global Compact: Program promoted by the UN that contains 10 principles of action. ▪ Ecovadis: International sustainability rating (score 84/100 in 2022). ▪ Carbon Disclosure Project (CDP):
Slide 23: Fulfilment of the Sustainable Development Goals (SDGs)
Fulfilment of the Sustainable Development Goals (SDGs) In the development of its activity, Ercros contributes to the fulfilment of the 17 SDGs set in the UN 2030 Agenda, although it has a special impact on: ▪ SDG 3: Health and well-being. ▪ SDG 6: Clean water and sanitation. ▪ SDG 7: Affordable and
Slide 24: Associations and participations
Associations and participations 24
Slide 25: Thank you
Thank you For more information Ercros, S.A. Aranjuez factory Paseo del Deleite, s/n 28300 Aranjuez Tel.: (+34) 918 090 340 E-mail: [email protected] www.ercros.es