Medtronic plc. · NYSE:MDT
Medtronic — Investor Presentation (August 2025)
25 slides from Medtronic's investor presentation, August 2025
Slide 1: Detection of Colonic Polyps and Early Colorectal Cancer: The PillCam COLON 2 System
DETECTION OF COLONIC POLYPS AND EARLY COLORECTAL CANCER THE PILLCAMTM COLON 2 SYSTEM
Slide 2: PillCam COLON 2 System: Minimally Invasive System to Aid in Polyp Detection
PILLCAMTM COLON 2 SYSTEM MINIMALLY INVASIVE SYSTEM TO AID COLORECTAL IN POLYP DETECTION CANCER IMPORTANCE OF EARLY DIAGNOSIS PRODUCT VALUE
Slide 3: Colorectal Cancer Is Multifactorial
COLORECTAL CANCER IS MULTIFACTORIAL COLORECTAL CANCER CAUSED BY ENVIRONMENTAL AND GENETIC FACTORS 1 IMPORTANCE OF EARLY DIAGNOSIS Modifiable risk factors: PRODUCT VALUE ► Diet ► Physical activity _______________________ ► Social behaviors (i.e., alcohol, smoking) ► Risk factors Incidence Non-modifia
Slide 4: CRC Is Common
CRC IS COMMON COLORECTAL CANCER AGE STANDARDIZED INCIDENCE RATES FOR CRC PER 100.000 1,8 MILLION 4 IMPORTANCE OF EARLY INDIVIDUALS IN 2018, BY SEX Male DIAGNOSIS Eastern Africa 7.7 7.8 Female CASES OF CRC IN 2018, Middle Africa 7.3 7.8 4 WORLDWIDE PRODUCT VALUE Northern Africa 8.6 10.0 Southern Afri
Slide 5: CRC Mortality Is High
CRC MORTALITY IS HIGH COLORECTAL CANCER 4 CUMULATIVE RISK (%) OF CRC MORTALITY (0-74 YEARS) IN 2018, BY SEX 880.792 Eastern Africa 0.62 0.68 Male Female IMPORTANCE OF EARLY DIAGNOSIS CRC DEATHS IN 2018, Middle Africa 0.64 0.64 4 WORLDWIDE Northern Africa 0.50 0.64 PRODUCT VALUE Southern Africa 0.57
Slide 6: Patient Burden
PATIENT BURDEN COLORECTAL CANCER CRC CARE LEADS TO CRC CAN LEAD TO IMPORTANCE OF EARLY DIAGNOSIS HOSPITALIZATION 8 MENTAL HEALTH PROBLEMS 9 PRODUCT VALUE 5,8-13,6 DAYS 29% 44% _______________________ RANGE OF DURATION OF OF PATIENTS OF PATIENTS Risk factors HOSPITALIZATION REPORTED REPORTED 8 9 9 IN
Slide 7: Economic Impact
ECONOMIC IMPACT COLORECTAL CANCER GLOBALLY: IN EUROPE: IMPORTANCE OF EARLY DIAGNOSIS $99 BILLION €13,1 BILLION 10% PRODUCT VALUE ECONOMIC IMPACT ECONOMIC IMPACT OF TOTAL _______________________ 10 11 OF CRC IN 2010 OF CRC IN 2009 ECONOMIC COST 11 OF CANCER IN 2009 Risk factors 22% Incidence DIRECT M
Slide 8: Diagnostic Tools
DIAGNOSTIC TOOLS COLORECTAL CANCER Non-invasive procedures IMPORTANCE OF EARLY DIAGNOSIS ► Stool-based tests (i.e., FIT, FIT-DNA, gFOBT): screening tests that can be performed 14 at home and that typically detect lesions at a more advanced stage PRODUCT VALUE _______________________ Minimally-invasi
Slide 9: Progression to CRC Depends on Lesion Subtype and Size
PROGRESSION TO CRC DEPENDS COLORECTAL CANCER ON LESION SUBTYPE AND SIZE IMPORTANCE OF EARLY DIAGNOSIS ADVANCED ADENOMAS AND ► 20% - 30% PRODUCT VALUE CRC cases SERRATED POLYPS develop from _______________________ CARRY THE HIGHEST RISK 16 serrated polyps Diagnostic tools FOR DEVELOPING INTO CRC 15 1
Slide 10: Positive Impact of Screening in Europe
POSITIVE IMPACT OF SCREENING IN EUROPE 19 COLORECTAL CANCER EARLY DETECTION IMPORTANCE OF EARLY DIAGNOSIS IMPROVES POPULATION HEALTH PRODUCT VALUE BY REDUCING CRC _______________________ INCIDENCE AND MORTALITY 20 Diagnostic tools ► Early detection Screening recommendations CRC mortality reduction v
Slide 11: Screening May Lead to Healthcare Savings
SCREENING MAY LEAD TO HEALTHCARE SAVINGS COLORECTAL CANCER NATIONAL IMPORTANCE OF EARLY DIAGNOSIS SCREENING PROGRAMS HAVE PRODUCT VALUE PROVEN TO BE _______________________ COST-EFFECTIVE 24 Diagnostic tools Driven by: ► Early detection ► Cost of screening Screening recommendations ► Screening test
Slide 12: CRC Screening Recommendations
CRC SCREENING RECOMMENDATIONS COLORECTAL CANCER 26 EU AND EUROPEAN SOCIETY OF GASTROINTESTINAL ENDOSCOPY IMPORTANCE OF EARLY DIAGNOSIS Screening tests and PRODUCT VALUE recommendations First line Third line* _______________________ Diagnostic tools Second line FIT Colonoscopy Capsule CTC FIT-DNA End
Slide 13: Polyp Resection
POLYP RESECTION COLORECTAL CANCER 27 EUROPEAN SOCIETY OF GASTROINTESTINAL ENDOSCOPY GUIDELINES IMPORTANCE OF EARLY Superficial colorectal neoplasia DIAGNOSIS PRODUCT VALUE Sessile or flat Pedunculated _______________________ Diminutive ≤5 mm Small size 6-9 mm Size ≥10 mm Head size <20 mm Head size ≥
Slide 14: European CRC Screening Programs
EUROPEAN CRC SCREENING PROGRAMS COLORECTAL CANCER MOST EUROPEAN COUNTRIES IMPORTANCE OF EARLY DIAGNOSIS HAVE IMPLEMENTED ORGANIZED SCREENING PRODUCT VALUE PROGRAMS 28* _______________________ ► Stool tests are mostly used as a first line Diagnostic tools screening test Early detection ► Colonoscopy
Slide 15: Challenges of Current Screening Programs
CHALLENGES OF CURRENT SCREENING PROGRAMS COLORECTAL CANCER Unnecessary colonoscopies can result from: 71%-79% IMPORTANCE OF EARLY DIAGNOSIS ► Low diagnostic performance of stool- POOLED SENSITIVITY RATES OF FIT IN THE PROXIMAL 29 14 AND DISTAL COLON based tests PRODUCT VALUE ► Low cut-off thresholds
Slide 16: PillCam COLON 2 System Developed to Address the Unmet Need
PILLCAM™ COLON 2 SYSTEM COLORECTAL CANCER DEVELOPED TO ADRESS THE UNMET NEED IMPORTANCE OF EARLY DIAGNOSIS PERFORMED COLONOSCOPIES 71% PRODUCT VALUE ► PCC-2 could37reduce the number of performed colonoscopies when used REDUCTION _______________________ as filter test , whereby unnecessary 38 costs c
Slide 17: Additional Benefits of PillCam COLON 2 System
ADDITIONAL BENEFITS OF PILLCAM™ COLON 2 SYSTEM COLORECTAL CANCER TRIAGE TOOL IMPORTANCE OF EARLY DIAGNOSIS ► PCC-2 can help to prioritize the backlog 42 of delayed elective procedures PRODUCT VALUE _______________________ SHIFT TO OUTPATIENT ► Value proposition SETTING Product overview ► PCC-2 can e
Slide 18: PillCam COLON 2 Platform
PILLCAM™ COLON 2 PLATFORM COLORECTAL CANCER The PCC-2 system consists of: IMPORTANCE OF EARLY DIAGNOSIS ► PillCam™ COLON 2 capsule, a wireless capsule with adaptive frame rate technology PRODUCT VALUE _______________________ ► PillCam™ Data Recorder 3, an external recorder that receives, transmits,
Slide 19: Safety
SAFETY MULTIPLE STUDIES HAVE DEMONSTRATED THE SAFETY COLORECTAL CANCER OF THE PCC-2 PROCEDURE43 IN ADULTS AND CHILDREN IMPORTANCE OF EARLY DIAGNOSIS These studies have show that PRODUCT VALUE Other picture – lifestyle / arts + stethoscoop Minor adverse events were reported, such as 44 ____________
Slide 20: Diagnostic Accuracy
DIAGNOSTIC ACCURACY PCC-2 DEMONSTRATED INCREASED DIAGNOSTIC COLORECTAL CANCER ACCURACY FOR 49, 51 LARGER POLYPS IMPORTANCE OF EARLY DIAGNOSIS PRODUCT VALUE COMPARED TO COLONOSCOPY COMPARED TO CTC _______________________ Visualization using PCC-2: Visualization using PCC-2: Value proposition ► Allowe
Slide 21: Sensitivity and Specificity
SENSITIVITY AND SENSITIVITY AND SPECIFICITY FOR PCC-2 IMPROVED WITH COLORECTAL CANCER SPECIFICITY INCREASING POLYP SIZE 41, 56 IMPORTANCE OF EARLY DIAGNOSIS These studies have shown that: 41 56 PRODUCT VALUE ► Sensitivity rates ranged from 57% for polyps ≤ 6 mm to 100% for polyps ≥ 10 mm , with high
Slide 22: Positive and Negative Predictive Values
POSITIVE AND NEGATIVE POSITIVE AND NEGATIVE PREDICTIVE VALUES FOR PCC- COLORECTAL CANCER PREDICTIVE VALUES 2 TEND TO INCREASE WITH 41, 49, 51 INCREASING POLYP SIZE IMPORTANCE OF EARLY DIAGNOSIS 49 49 ► Positive predictive values ranged from 57,4% for polyps ≤ 6 mm to 80,7% for polyps ≥ 10 mm 41 41 P
Slide 23: Economic Evidence
ECONOMIC EVIDENCE PCC-2 HAS THE POTENTIAL TO REDUCE HEALTHCARE COSTS COLORECTAL CANCER FROM A PUBLIC HEALTH 37,38,62 AND PAYER PERSPECTIVE IMPORTANCE OF EARLY DIAGNOSIS CRC screening with PCC-2 could be cost- PRODUCT VALUE effective at moderate additional costs: _______________________ ► A cost anal
Slide 24: Patients Preference
39 PATIENTS PREFERENCE PCC-2 IS WELL-TOLERATED AND PREFERED41,OVER OTHER COLORECTAL CANCER 61, 63 DIAGNOSTICS IMPORTANCE OF EARLY DIAGNOSIS PCC-2 IS A MINIMALLY INVASIVE AND PATIENT FRIENDLY PRODUCT VALUE METHOD FOR THE VISUALIZATION OF THE COLON 39 _______________________ Value proposition COMPARED
Slide 25: Risk Information and Indications for Use
Risk Information: The risks of the PillCam™ COLON 2 capsule include capsule retention, aspiration, and skin irritation, perforation, obstruction, mucosal injury, and bleeding. The risks associated with colon preparation are allergies or other known contraindications to any preparation agents or medi