Altria Group, Inc. · NYSE:MO
Altria — Technical Presentation (October 2018)
16 slides from Altria's technical presentation, Oct 26, 2018
Slide 1: E-cigarette Aerosol Dynamics in a Physical Model of the Adult Human Oral/Pharyngeal/Tracheal Cavity
E-cigarette Aerosol Dynamics in a Physical Model of the Adult Human Oral/Pharyngeal/Tracheal Cavity WANG Q.; LI W. ;CASTRO N.; ZHANG J.; PITHAWALLA Y.; OLDHAM M.; KANE D.; and ROSTAMI A. A. Altria Client Services LLC, Center for Research & Technology, 601 E. Jackson Street, Richmond, VA 23219 Altria
Slide 2: Objective
Objective To generate experimental data to validate a computational fluid dynamic (CFD) model for e-cigarette aerosol deposition in respiratory tract Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 2
Slide 3: Physical Model
Physical Model - Physical Prototypes created from - Wall covered with a layer of cotton cloth digital geometry using 3D printer that can be saturated with water to reflect high relative humidity in respiratory tract Oral/Larynx/Pharynx/Tracheal section Inlet Outlet Altria Client Services l W. Li l 1
Slide 4: Diagram of the Experimental Setup
Diagram of the Experimental Setup Physical Model E-Cig Oven (set at 37 ̊C) 3-way valve Temp. & controller Probe RH 1.1lpm Ambient Cambridge Air Probe Pad Vacuum 1.1 lpm Flow Calibrator High Efficiency Mass Switch filter Flowrate controller Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 4
Slide 5: Experimental Conditions
Experimental Conditions puff duration Case E-liquid composition puff volume (cc) Temperature (C) Wall conditions (sec.) 2.5% Nicotine by weight (NBW), 15% water, N-1 3 55 37 wet 49.5% PG/Gly 33% N-2 2.5% NBW, 15% water, 49.5% PG/Gly 33% 3 55 37 dry N-3 2.5% NBW, 10% water, 87.5% PG 3 55 37 wet N-4 2
Slide 6: Gravimetric Analysis
Gravimetric Analysis Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 6
Slide 7: Results – Gravimetric Analysis
Results – Gravimetric Analysis 2.5% NBW, 15% water, 49.5% PG/Gly 33% 8.0 8.0 Cartridge #1 Cartridge #1 Aerosol mass per puff, mg wet dry Aerosol mass per puff, mg Cartridge #2 Cartridge #2 6.0 Cartridge #3 6.0 Cartridge #3 4.0 4.0 2.0 2.0 0.0 0.0 Upstream Downstream Upstream Downstream Physical mode
Slide 8: Results – Gravimetric Analysis
Results – Gravimetric Analysis wet, 2.2 times increase wet, 2.9 times increase 8.0 8.0 Cartridge #1 Cartridge #1 Cartridge #2 Aerosol mass per puff, mg Cartridge #2 Aerosol mass per puff, mg 6.0 Cartridge #3 6.0 Cartridge #3 4.0 4.0 2.0 2.0 0.0 0.0 Upstream Downstream Upstream Downstream 2.5% NBW, 1
Slide 9: Chemical Analysis
Chemical Analysis Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 9
Slide 10: Results – Chemical Analysis (wet)
Results – Chemical Analysis (wet) 2.5% NBW, 15% water, 49.5% PG/Gly 33% 1400 60 Upstream Upstream 1200 Mass per Puff (µg) Mass per Puff (µg) Downstream Downstream 1000 40 800 600 20 400 200 0 0 Nic. GLY PG Nic. Physical model Nicotine deposition,% Oral/Pharyngeal 48 Oral/Pharyngeal/ Tracheal 63 Altr
Slide 11: Results – Chemical Analysis (dry)
Results – Chemical Analysis (dry) 1400 Upstream 60 1200 Downstream Upstream Downstream Mass per Puff (µg) 1000 Mass per Puff (µg) 40 800 600 20 400 200 0 0 Nic GLY PG Nic. 2.5% NBW, 15% water, 49.5% PG/Gly 33% Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 11
Slide 12: Nicotine Is Hydrophobic
Nicotine Is Hydrophobic 10 ml water solution (contained 2.5% nicotine) mixed with 10 ml octanol Abundance Retention time --- nicotine in octanol --- nicotine in water Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 12
Slide 13: Results – Chemical Analysis (wet)
Results – Chemical Analysis (wet) 80 80 Upstream Upstream Downstream Downstream Mass per Puff (µg) Mass per Puff (µg) 60 60 40 40 20 20 0 0 Nic. Nic. 2.5% NBW, 10% water, 87.5% PG 4.5% NBW, 10% water, 85.5% Gly Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 13
Slide 14: Summary
Summary • Particle size and Nicotine deposition increases as the length of the physical model increases • Nicotine deposition increases as a result of hygroscopic growth due to hydrophobicity of Nicotine • The deposition of Nicotine is higher in Glycerin & water than in PG & water Altria Client Serv
Slide 15: Thank You!
Thank You! Altria Client Services l W. Li l 10/26 l 2018 CORESTA l 15
Slide 16: For copies of this presentation visit the Altria Science Website
For copies of this presentation visit the Altria’s Science Website at www.altria.com/alcs-science Altria Client Services l Owner Name l Date l 2018 CORESTA l 16