Yield10 Bioscience, Inc. · OTC:YTENQ
Yield10 Bioscience — IPO Roadshow (December 2017)
33 slides from Yield10 Bioscience's IPO roadshow presentation, Dec 11, 2017
Slide 1: Forward-looking statements
The statements made by Yield10 Bioscience, Inc. (the “Company,” “we,” “our” or “us”) herein regarding the Company and its business may be forward-looking in nature and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements
Slide 2: Offering disclaimer and registration statement notice
This presentation highlights basic information about us and the offering. Because it is a summary that has been prepared solely for informational purposes, it does not contain all of the information that you should consider before investing in our company. Except as otherwise indicated, this present
Slide 3: Yield10 investment considerations
“Yield10 designs precise alterations to gene activity in food and feed crops to produce higher yields with lower inputs of land, water or fertilizer” Leverages a large historical investment in advanced metabolic engineering into the Ag space • 15 recent patent applications for increased crop yield A
Slide 4: Yield10 investment considerations
siderations Vv y “Yield10 designs precise alterations to gene activity in food and feed crops to produce higher yields with lower inputs of land, water or fertilizer” Leverages a large historical investment in advanced metabolic engineering into the Ag space + 15 recent patent applications for incre
Slide 5: Yield10 Bioscience developing technologies to enhance global food security
Yield10 Bioscience (Nasdaq:YTEN) is developing technologies to enhance global food security • Headquartered in Woburn, MA USA • Oilseeds center of excellence in Saskatoon, Canada Yield10 is bringing extensive expertise and track record in optimizing the flow of carbon in living systems to the agricu
Slide 6: Yield10 Bioscience developing technologies to enhance global food security
I Vv Yield10 Bioscience (Nasdaq:YTEN) is developing technologies to enhance global food security + Headquartered in Woburn, MA USA * Oilseeds center of excellence in Saskatoon, Canada Yield10 is bringing extensive expertise and track record in optimizing the flow of carbon in living systems to the a
Slide 7: Increasing Crop Yield is Valuable but Technically Very Challenging
Increasing Crop Yield is Valuable but Technically Very Challenging • First generation Ag biotech is based on using microbial genes in crops (early 90’s) • Over the last 20 years transgenic screening of thousands of single plant genes has failed • Development of modern corn from ancient teosinte prov
Slide 8: Increasing Crop Yield is a Multi-Gene Problem
Increasing Crop Yield is a Multi-Gene Problem Road map A CO2 Metabolic map 2800 traffic lights Seed yield “roadmap analogy B Corn ~2400 transcription factor genes Seed Traffic regulators Road infrastructure Metabolic infrastructureGene regulators • Yield10: Two discovery platforms • “Smart Carbon Gr
Slide 9: Summary of our crop yield traits in development
SUMMARY OF OUR CROP YIELD TRAITS IN DEVELOPMENT Business Area Current Status Seed Yield Traits-Regulated C3003 Camelina 1st and 2nd generation at field testing stage Canola 1st generation at field testing stage Soybean and rice in development Seed/Oil Enhancing Traits-Non-Regulated C3004 Camelina te
Slide 10: Rich Pipeline of Trait Genes in Development
Rich Pipeline of Trait Genes in Development V y ‘SUMMARY OF OUR CROP YIELD TRAITS IN DEVELOPMENT Business Area Current Status Seed Yield Traits-Regulated Camelina 1° and 2" generation at field stage Many opportunities 3003 Canola 1* generation at field testing stage . . . Soybean and rice in develop
Slide 11: Aligned with compelling megatrends
Yield10 is…….Aligned with compelling megatrends 9 October 2009; Revised June, 2015 GA/EF/3242 Food Production Must Double by 2050 Global Food Security…… increasing overall demand and increased protein consumption Health and Wellness.....improved nutrition profile Food Safety and Sustainability…..gro
Slide 12: Next Phase of High-Tech Crops, Editing Their Genes
Next Phase of High-Tech Crops, Editing Their Genes (May 7, 2017 By Jacob Bunge) •Genome editing completes the toolbox for enhancing crop yield and value •Genome editing enables Precision Molecular Breeding of gene combinations for enhancing crop yield •Genome edited plants may be non-regulated reduc
Slide 13: Research license to C3003 and C3004 in soybean (Monsanto)
Research license to C3003 and C3004 to improve yield in soybean • Market leader in GM soybean seed in the United States and North America • Non-exclusive term of approx. 3.5 years, preserves YTEN downstream rights • Develop and test C3003 in proprietary soybean lines • Develop and test C3003 combine
Slide 14: Monsanto seeds and genomics segment net sales
Monsanto’s net sales for the seeds and genomics segment was $10.9 billion in FY 2017. • The seeds and genomics segment produces seed brands and develops biotechnology traits. MONSANTO’S SEEDS AND GENOMICS SEGMENT1 – FY 2011 - 2017 $12,000 $10,000 $695 $665 $523 $440 $615 $815 $ millions $6,000 $847
Slide 15: Value Creation Model: Seed Yield and Oil Content
Value Creation Model: Seed Yield and Oil Content Yield10’s gene traits may enable value creation through step-change increases in crop yield An illustrative example of the annual revenue opportunity for Yield10’s canola, soybean and corn gene traits based on the 2016 harvest. Canola(1) (Can) 2016 Ha
Slide 16: Yield10 Traits: Market Doubleplay
Yield10 Traits: Market Doubleplay CropValue PropositionCompetitive Advantage Commodity • Corn • Soybean • Canola • Reduce grower cost • Increase production • Lower food costs • Food security • Sustainability • Novel yield traits • Powerful trait gene combination discovery platform High performance t
Slide 17: Commercial Strategy
Commercial Strategy Yield10 Technologies Enable Multiple Paths to Value Creation Driven by Yield Traits and Unique Capabilities Major North American Commodity Crops Accelerate deployment with Ag majors Provide low hurdle to deploy and test yield traits in elite germplasm License agreements wit
Slide 18: Commercial Strategy
Commercial Strategy vV y Yield10 Technologies Enable Multiple Paths to Value Creation Driven by Yield Traits and Unique Capabilities Major North American Commodity Crops = Accelerate deployment with Ag majors = Provide low hurdle to deploy and test yield traits in elite germplasm * License agreement
Slide 19: Yield10 working to progress yield enhancement technologies and build collaborations
Yield10 is working to progress our yield enhancement technologies and build collaborations • Continue progress on C3003 with additional constructs and crops •Begin planning and logistics for 2018 field testing of C3003 in Camelina and canola in Canada •Work with Monsanto to set up testing program in
Slide 20: Indicative Proof Point Timelines for C3003
Indicative Proof Point Timelines for C3003 Year 2017 2018 2019 Camelina/Gen 1 C3003 Field test data (Q1) Camelina/Gen 2 C3003 Greenhouse data (Q1) Field test data (Q4) Field test data (Q4) Canola/Gen 1 C3003 Field test data (Q4) Field test data (Q4) Field trial Canola/Gen 2 C3003 Field test
Slide 21: Plans for 2018 Field Tests and Early Development Activities
Plans for 2018 Field Tests and Related Discovery & Early Development Activities Goal: Identify best constructs/events to move into larger scale field studies Camelina • Field tests with best lines with Gen 2.0 and Gen 2.1 constructs using field grown seed • Continue research on Gen 3 C3003 construct
Slide 22: Plans for 2018 Field Tests and Early Development Activities
Ce Y il Plans for 2018 Field Tests and Related Discovery & Early Development Activities Goal: Identify best constructs/events to move into larger scale field studies Camelina + Field tests with best lines with Gen 2.0 and Gen 2.1 constructs using field grown seed * Continue research on Gen 3 C3003 c
Slide 23: Novel Yield Trait Gene: C3003
Novel Yield Trait Gene: C3003 C3003 is a component of an algal system for increasing photosynthesis in low CO2 conditions • A scientific discovery from University of Massachusetts with a unique biological mechanism • C3003 improves the metabolic infrastructure of the plants • Potential to be useful
Slide 24: First Field Test with Gen 2.0 C3003 Shows Promising Results in Camelina
First Field Test with Gen 2.0 C3003 Shows Promising Results in Camelina Objectives • Generate technical data and determine the best way to deploy C3003 in canola and soybean Results • Solid agronomic profile: seed germination, seedling vigor • Overall seed yield results positive but varied between t
Slide 25: Gen C3003 Camelina Mini Cage/Seed Bulk Up Results
Gen 2 C3003 Camelina Mini Cage/Seed Bulk Up Results Mini Cage Results Provide Insight into Optimizing Expression of C3003 in Oilseed Crops Objectives and Growth Conditions • Produce pure field grown seed for 2018 field testing program • Compare 2 different seed specific promoters (Gen 2.0 and 2.1 co
Slide 26: First Field Test Shows Translation of Yield Trait into Canola
First Field Test with Gen 1 C3003 Shows Translation of Yield Trait into Canola Objectives • Determine if seed yield improvement and agronomic attributes observed for C3003 in Camelina translate to canola • Test several events and select best ones for further study Results • Observed seed yield impro
Slide 27: Traits for Boosting Seed Oil Content
Yield10:Traits for Boosting Seed Oil Content USDA-APHIS confirmed nonregulated status for our genome-edited C3008a Camelina line • First nonregulated trait (C3008a) submission to USDA-APHIS by Yield10 • Developing multi-gene edited oilseed lines (C3008a, b, C3009) for future submission • C3007 and C
Slide 28: C4001 boosts photosynthesis and improves plant biomass yield
• C4001 boosts a key parameter of photosynthesis (~75%) and improves plant biomass yield (~75-100%) in switchgrass • Transformed rice with C4001 gene from switchgrass and rice • 1st generation plants are growing in greenhouse • Produce 3rd generation plants and measure seed yield • Signed two-year c
Slide 29: Key Accomplishments & Capitalization Table
KEY ACCOMPLISHMENTS & CAPITALIZATION TABLE
Slide 30: 2017 key accomplishments
Achieved all major objectives for 2017 while managing cash usage Kicked off 2017 with renaming and rebranding as Yield10 Bioscience, Inc. Added 2 key scientists and board member with agricultural business experience Conducted Field Tests for C3003 in Camelina and canola Reported encouragin
Slide 31: Capitalization table
*Strike price for 393,300, 570,784, and 30,000 warrants is $39.80, $5.04, and $2.90, respectively.
Slide 32: Yield10 Bioscience, Inc. (NASDAQCM:YTEN)
Yield10 Bioscience, Inc. (NASDAQCM:YTEN) Investor Presentation Yield10 is developing new technologies to achieve step-changes in crop yield to enhance global food security December 2017 Filed pursuant to Rule 433 Registration Statement No. 333-221283 December 11, 2017
Slide 33: Yield10 Bioscience, Inc. December 2017
Filed pursuant to Rule 433 e Registration Statement No. 333-221283 \ ho Vi e ! d 1 O December 11, 2017 BIOSCIENCE . Yield10 Bioscience, Inc. (NASDAQCM:YTEN) Investor Presentation Yield10 is developing new technologies to achieve step-changes in crop yield to enhance global food security December 201