Altria Group, Inc. · NYSE:MO
Altria — Technical Presentation (June 2022)
37 slides from Altria's technical presentation, Jun 22, 2022
Slide 1: The Harm Reduction Potential of Oral Tobacco Derived Nicotine Products
The Harm Reduction Potential of Oral Tobacco Derived Nicotine Products Elizabeth Becker Senior Director, Population Science Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 1
Slide 2: Altria's Approach to Harm Reduction
Altria’s Approach to Harm Reduction Harm Reduction Potential of OTDNs Reduced Adult Tobacco Accurate Harm Consumer Communications Interest & Use Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 2
Slide 3: Altria's Approach to Harm Reduction
Altria’s Approach to Harm Reduction Harm Reduction Potential of OTDNs Reduced Adult Tobacco Accurate Harm Consumer Communications Interest & Use Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 3
Slide 4: Tobacco Harm Reduction Framework
Tobacco Harm Reduction Framework Traditional Decrease Increase Strategies Initiation Cessation Tobacco Harm Reduction Framework Complement to Switching ATC Accelerate to Less Harmful Smoking-Related Existing Approach Products Harm Reduction ATC=Adult Tobacco Consumers Elizabeth Becker | Altria Clien
Slide 5: Tobacco Harm Reduction Framework
Tobacco Harm Reduction Framework Traditional Decrease Increase Strategies Initiation Cessation Tobacco Harm Reduction Framework Complement to Switching ATC Accelerate to Less Harmful Smoking-Related Existing Approach Products Harm Reduction ATC=Adult Tobacco Consumers Elizabeth Becker | Altria Clien
Slide 6: Current Tobacco Product Use Among High School Students, 2011-2021
Current Tobacco Product Use Among High School Students, National Youth Tobacco Survey, 2011-2021 Cigarettes Smokeless Tobacco E-Cigarettes Nicotine Pouches 35 30 27.5 25 Percentage (%) 20.8 19.6 20 16.0 15.8 14.0 15 12.7 13.4 11.3 11.7 9.2 9.3 11.3 10 8.0 7.6 8.1 7.3 6.4 5.7 5.8 4.6 5 6.0 5.8 5.9 5.
Slide 7: Tobacco Harm Reduction Framework
Tobacco Harm Reduction Framework Traditional Decrease Increase Strategies Initiation Cessation Tobacco Harm Reduction Framework Complement to Switching ATC Accelerate to Less Harmful Smoking-Related Existing Approach Products Harm Reduction ATC=Adult Tobacco Consumers Elizabeth Becker | Altria Clien
Slide 8: Responsibly lead the transition of adult smokers to a smoke-free future
Responsibly lead the transition of adult smokers to a SMOKE-FREE FUTURE Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 8
Slide 9: The Problem: Harm Caused from Cigarette Smoking
The Problem: Harm Caused from Cigarette Smoking COMBUSTIBLE TOBACCO – MOST HAZARDOUS FORM OF TOBACCO 30.8MILLION OVERWHELMING Cigarette smoking is addictive and causes serious diseases including: US adult smokers1 EVIDENCE Lung cancer Emphysema Cardiovascular disease ~443,000 U.S. Deaths Attributabl
Slide 10: Risk Cliff
Risk Cliff Risk Cliff Between Combustible & Higher Risk Combustible Smoke-Free Tobacco1 Tobacco Products Lower Smoke-Free Risk Tobacco Products 1 Adapted from Nutt, et. Al Estimating the Harms of Nicotine-Containing Products Using the MCDA Approach. Eur. Addict Res 2014; 20:218-225. Elizabeth Becker
Slide 11: Perceived Harmfulness of Tobacco Products Compared to Smoking Cigarettes
Perceived Harmfulness of Tobacco Products Compared to Smoking Cigarettes, PATH Wave 4 Adult Tobacco Users Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 11
Slide 12: Harm Misperceptions of E-Vapor
Harm Misperceptions of E-Vapor1 ? 100% Wave 1 Wave 2 Wave 3 Wave 4 (2013-2014) (2014-2015) (2015-2016) (2016-2018) ADULT SMOKERS’ ASKED 75% 67.2% Is using e-cigarettes or other electronic 50% 47.3% 40.7% nicotine products less harmful, about the same, or more 25% 20.7% harmful than 10.5% 6.9% 5.1% s
Slide 13: Percent of Smokers Who Switched to E-Vapor or Smokeless Tobacco
Percent of Smokers Who Switched to E-Vapor or Smokeless Tobacco the Following Year Switched to Switched to 4 E-vapor Smokeless Tobacco 3.5 3 KEY TAKEAWAY Percent Switched Smokers with an accurate perception of risk are 2 2-3x MORE LIKELY TO SWITCH 1 1.1 0.9 0.4 0 Misperception Believed e-vapor Mispe
Slide 14: Altria's Approach to Harm Reduction
Altria’s Approach to Harm Reduction Harm Reduction Potential of OTDNs Reduced Adult Tobacco Accurate Harm Consumer Communications Interest & Use Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 14
Slide 15: on! Harm Reduction Opportunity
on!® Harm Reduction Opportunity on!® nicotine pouches have the most variety of any nicotine pouches currently in the U.S. Market SEVEN FLAVORS 5 NICOTINE STRENGTHS 1.5 2 3.5 4 8 MG MG MG MG MG Nicotine NO TOBACCO LEAF pouches All flavors are available for purchase through e-commerce. Select SKUs are
Slide 16: Scientific Framework
Scientific Framework CONSTITUENT INDIVIDUAL RISK POPULATION HARM REDUCTION REDUCTION REDUCTION Risks and Product Chemical Toxicology Studies in Perception Benefits to Design and and Physical and Risk Adult Human and Behavior Health of the Control Characterization Assessment Subjects Assessment Popul
Slide 17: Scientific Framework
Scientific Framework CONSTITUENT INDIVIDUAL RISK POPULATION HARM REDUCTION REDUCTION REDUCTION Risks and Product Chemical Toxicology Studies in Perception Benefits to Design and and Physical and Risk Adult Human and Behavior Health of the Control Characterization Assessment Subjects Assessment Popul
Slide 18: Percent Reduction in HPHC Levels in on! Compared to Cigarettes
Percent Reduction in HPHC Levels in on!® Nicotine Pouches Compared to Cigarettes 100% Reference CONSTITUENT REDUCTION Cigarette 80% 60% >99% lower levels than cigarettes 40% Not detectable in the BLOQ in the on!® Nicotine Pouches on!® Nicotine Pouches Percent reduction not calculated Percent reducti
Slide 19: HPHCs in on! Absent or Reduced Compared to General Snus
HPHCs in on!® Nicotine Pouches are Absent or Substantially Reduced Compared to General® Snus 100% Reference CONSTITUENT REDUCTION General® Snus 80% 60% >98% lower levels than General® Snus 40% Not detectable or BLOQ in the on!® Nicotine Pouches 20% Percent reduction not calculated 0% NNK NNN B[a]P A
Slide 20: Scientific Framework
Scientific Framework CONSTITUENT INDIVIDUAL RISK POPULATION HARM REDUCTION REDUCTION REDUCTION Risks and Product Chemical Toxicology Studies in Perception Benefits to Design and and Physical and Risk Adult Human and Behavior Health of the Control Characterization Assessment Subjects Assessment Popul
Slide 21: Risk Assessment of Non-Tobacco Ingredients
Risk Assessment of Non-Tobacco Ingredients Demonstrates Levels Below Acceptable Daily Intake INDIVIDUAL RISK REDUCTION Our Risk Assessment of Non-Tobacco Ingredients indicates Exposure is Below Acceptable Daily Intake Values as Established by Authoritative Bodies* on!® Nicotine Pouches Most ingredie
Slide 22: The on! Portfolio Delivers a Wide Range of Nicotine
The on!® Portfolio Delivers a Wide Range of Nicotine INDIVIDUAL RISK REDUCTION 16 Mint 8 mg Mint 4 mg 14 Mint 3.5 mg Mint 2 mg Plasma Nicotine Conc. (ng/ml) 12 Mint 1.5 mg 10 8 6 4 2 0 0 20 40 60 80 100 120 140 160 180 Time (minutes) Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs
Slide 23: Abuse Potential Lower Than or Similar to Cigarettes or ST Products
Abuse Potential is Lower Than or Similar to That of Cigarettes or ST Products and Not Impacted by Flavor Plasma Nicotine Values Over Time During Use of the 8mg NP and Representative Published data INDIVIDUAL RISK REDUCTION Cigarettes Smokeless Tobacco Products Plasma Nicotine Concentration [ng/mL] P
Slide 24: Altria's Approach to Harm Reduction
Altria’s Approach to Harm Reduction Harm Reduction Potential of OTDNs Reduced Adult Tobacco Accurate Harm Consumer Communications Interest & Use Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 24
Slide 25: Scientific Framework
Scientific Framework CONSTITUENT INDIVIDUAL RISK POPULATION HARM REDUCTION REDUCTION REDUCTION Risks and Product Chemical Toxicology Studies in Perception Benefits to Design and and Physical and Risk Adult Human and Behavior Health of the Control Characterization Assessment Subjects Assessment Popul
Slide 26: Perception & Behavioral Intentions Study Among Users and Nonusers
Perception & Behavioral Intentions Study Among Users and Nonusers Participants Exposure to Measures POPULATION HARM REDUCTION Promotional Materials Intentions to Use Tobacco Users + Purchase Interest Tobacco Nonusers = Likelihood to Use 26 Elizabeth Becker | Altria Client Services LLC | Regulatory A
Slide 27: Adult Tobacco Users Classified as Likely to Use on! Nicotine Pouches
Moderate to Large Proportion of Adult Tobacco Users Classified as Likely to Use on!® Nicotine Pouches POPULATION HARM REDUCTION Pre-test Post-test 100% 80% 62% 59% Likelihood 60% 54% 55% 52% 51% 38% 38% 40% 35% 35% 20% 0% ASPQ ASNPQ ST Users Dual Users LA-24 Users (n=330) (n=330) (n=333) (n=331) (n=
Slide 28: Adult Tobacco Nonusers Classified as Likely to Use on!
Small Proportions of Adult Tobacco Nonusers Classified as Likely to Use on!® Nicotine Pouches POPULATION HARM REDUCTION 100% Pre-test Post-test 80% 62% 59% Likelihood 60% 54% 55% 52% 51% NONUSERS 38% 38% 40% 35% 35% 20% 9% 11% 3% 4% 4% 5% 0% Former Users Never Users LA-24 ASPQ ASNPQ ST Users Dual Us
Slide 29: Actual Use Study of on! Nicotine Pouches
Actual Use Study of on!® Nicotine Pouches POPULATION HARM REDUCTION Participants Free Selection of Outcomes Product Complete Switching Tobacco Users Reduction in Interested in Using on!® Nicotine Pouches and Cigarette or Daily and Weekly Diaries not planning to quit Smokeless Tobacco Use 29 Elizabet
Slide 30: Adult Tobacco Users Switched or Reduced Traditional Tobacco Usage
Large Proportions of Adult Tobacco Users Switched or Reduced Traditional Tobacco Usage POPULATION HARM REDUCTION SWITCHED Adult Smokers n=399 28% COMPLETELY to on!® 72% Adult Dippers n=353 Nicotine Pouches Reduced cigarette consumption by Adult Smokers n=399 39% 50% or more 14% Adult Dippers n=353 R
Slide 31: Interest and Use of All Flavor Varieties
Interest and Use of All Flavor Varieties POPULATION HARM REDUCTION Product Likeability, Prevalence, and Purchase Interest by Variety Among Adult Smokers 31 Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 |
Slide 32: Reasons for Future Use of on! Nicotine Pouches
POPULATION HARM REDUCTION Reasons for Future Use of on!® Nicotine Pouches Perception Risks and Benefits to Among Adult Smokers Likely to Use on!® Nicotine Pouches and Behavior Health of the Assessment Population POPULATION HARM REDUCTION To help prevent relapse to smoking 22% To help cut back or qui
Slide 33: Altria's Approach to Harm Reduction
Altria’s Approach to Harm Reduction Harm Reduction Potential of OTDNs Reduced Adult Tobacco Accurate Harm Consumer Communications Interest & Use Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 33
Slide 34: Scientific Evidence Included in Our MRTPA
Scientific Evidence Included in Our MRTPA CHEMICAL ANALYSES TOXICOLOGICAL RISK BIOMARKERS ACTUAL USE EPIDEMIOLOGY (HPHCs and Stability) ASSESSMENTS OF EXPOSURE STUDY on!® Nicotine Pouches, as they are actually used by consumers, WILL SIGNIFICANTLY REDUCE HARM and the risk of tobacco-related disease
Slide 35: MRTPA Path Forward
MRTPA Path Forward OVERCOME MISPERCEPTIONS OPTIMIZE CLAIM SUBMIT MRTPAS AND BARRIERS TO TRANSITION COMMUNICATIONS TO ACCELERATE TRANSITION Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 35
Slide 36: Advancing Tobacco Harm Reduction
Advancing Tobacco Harm Reduction Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 36
Slide 37: Questions?
Any Questions? Elizabeth Becker | Altria Client Services LLC | Regulatory Affairs | Next Generation Nicotine Delivery | June 22, 2022 | 37