Brain Biotech Ag · XETR:BNN
Brain Biotech — Investor Day (February 2023)
18 slides from Brain Biotech's investor day presentation, Feb 27, 2023
Slide 1: BRAIN Biotech AG Capital Markets Day 2023
BRAIN Biotech AG Creating a #BiobasedFuture Capital Markets Day 2023 Zwingenberg, February 27, 2023 Since 2021 we have been committed to the UN Global Compact corporate responsibility initiative and its principles in the areas of human rights, labor, the environment and anti-corruption. Creating a #
Slide 2: The Engine for a #Biobased Future: BioScience Zwingenberg
Capital Markets Day 2023 Creating a #BiobasedFuture The Engine for a #Biobased Future: BioScience Zwingenberg Dr. Alexander Pelzer, Head R&D Creating a #BiobasedFuture © BRAIN Biotech AG Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0 55
Slide 3: Introduction – Dr. Alexander Pelzer
Introduction – Dr. Alexander Pelzer Head of R&D • 2005: Biology at Heinrich Heine University in Duesseldorf • 2010: PhD at Juelich Research Center • Institute for Molecular Enzyme Technology (IMET) • Scholarship CLIB-Graduate Cluster Industrial Biotechnology • BRAIN Biotech job evolution: 2014: Rese
Slide 4: Future Nutrition will be Produced Differently
Future Nutrition will be Produced Differently cornerstones of sustainable food production Why? • Industrial livestock farming has a significant GHG footprint • Fishing grounds are being depleted • May be considered unethical and contributes to the global antibiotics crisis • Energy, water and land u
Slide 5: Future Nutrition will be Produced Differently
Future Nutrition will be Produced Differently cornerstones of sustainable food production Precision fermentation Enzymes Microorganisms Alternative proteins Processing of plant-based protein Fermented food ► Industrialized countries will move away from meat and dairy towards alternative sources Crea
Slide 6: Biotechnology will be The Key Enabler
Biotechnology will be The Key Enabler future nutrition and materials will be more sustainable ► Future nutrition will be produced differently • Alternative proteins as protein source via precision fermentation • Enzymes are versatile helpmates for processing and optimizing food sources • Microorgani
Slide 7: BRAIN R&D – An Integrated Solutions Provider
BRAIN R&D – An Integrated Solutions Provider superior bio-based solutions for our customers Creativity and diversity of nature Enzymes & Proteins Microorganisms Bioprocesses Technology units Enzymes & Biocatalysts Strain Development Bioprocess Development Technology fields Function-driven discovery
Slide 8: BRAIN BioArchive: Valuable Resource for Microorganisms, Proteins & Enzymes
BRAIN BioArchive: Valuable Resource for Microorganisms, Proteins & Enzymes access biodiversity and use nature's solutions for our challenges Creativity and diversity of nature BRAIN BioArchive Value culture collection including Powerful discovery pipelines • Food collection (~ 600 strains) • Functio
Slide 9: Microorganisms for Future Nutrition
Microorganisms for Future Nutrition discovery & development of microorganisms Starter cultures (single & co-cultures) • Non alcoholic beverages • Fermented grape leaves to produce non alcoholic wine alternatives • Alternative protein • Fermented brewer's grains to enrich amino acid profile as optimi
Slide 10: Microorganisms are Versatile All-Rounders
Microorganisms are Versatile All-Rounders discovery & development of microorganisms CleanTech BioSolutions – Waste to value PGM from Catalysts Bioflotation of gold ores Copper recovery from black shale minerals Further application of microorganisms Development of microorganisms • New and improved ba
Slide 11: SeqPool: A Digital Sequence Database
SeqPool: A Digital Sequence Database proprietary database for fast enzyme & protein discovery Rational bioprospecting BRAIN9s SeqPool ~150 m. ORFs 323 m. UniRef100 ORFs > 50 metagenomes, selected & enriched organisms ► Fast discovery of new enzymes & proteins in SeqPool or in custom made data sets C
Slide 12: Designed and Tailor-made For Application
Designed and Tailor-made For Application rational engineering of enzymes & proteins Sequence-/structure-based engineering Bioinformatics guided rational approach Structure modelling MD simulations Docking studies Multiple sequence alignments ► Efficient combination of different disciplines enables t
Slide 13: Designed and Tailor-made For Application
Designed and Tailor-made For Application rational engineering of enzymes & proteins Bio-based performance materials Enzymes for glucose alternative synthesis 25 October 2022 8 February 2023 Creating a #BiobasedFuture © BRAIN Biotech AG Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0 66
Slide 14: Focus on Developing Strong Protein & Enzyme Producers
Focus on Developing Strong Protein & Enzyme Producers production strain development and bioprocess development go hand in hand Production strains: Escherichia coli, Bacillus subtilis, Pichia pastoris, Yarrowia lipolytica, Aspergillus niger Good starting situations to build on Development of producti
Slide 15: Focus on Developing Strong Protein & Enzyme Producers
Focus on Developing Strong Protein & Enzyme Producers production strain development and bioprocess development go hand in hand Goal: Development of a portfolio of fermentation processes with an <out of the box= g/L yield for the production strains • Implementation started and ongoing: Upstream Downs
Slide 16: Focus on Developing Strong Protein & Enzyme Producers
Focus on Developing Strong Protein & Enzyme Producers production strain development and bioprocess development go hand in hand Nutritional alternative protein 10 February 2022 8 February 2023 Creating a #BiobasedFuture © BRAIN Biotech AG Zwingenberg Germany www.brain-biotech.com +49 (0) 6251-9331-0
Slide 17: From Candidates to Industrial Production Processes
From Candidates to Industrial Production Processes all the technologies available to deliver the complete process Discovery Industrial Protein Engineering production Rational Selection Microbial strains Expression technology Strain development Bioprocess development Creating a #BiobasedFuture © BRAI
Slide 18: The Engine of a #Biobased Future
The Engine of a #Biobased Future fueled by passion for science and the motivation to create sustainable industries Tailor made solution (TMS) business BRAIN BioProducts Incubator pipeline - The Engine - BRAIN Biotech R&D ► BRAIN offers extensive experience and technical capabilities ► BRAIN customer