Ortivus Ab Class A · OMXSTO:ORTI_A
Ortivus Ab Class A — Investor Presentation (2009)
13 slides from Ortivus Ab Class A's investor presentation, 2009
Slide 1: Integrated FFR-measurement
Accurate treatment in time Integrated FFR- measurement 1 Copyright © 2009 Ortivus AB
Slide 2: CoroNet PCI-monitor
Accurate treatment in time CoroNet PCI-monitor • Online ischemia monitoring updated every 10th second • Full monitoring capacity • Measurement of intra coronary pressure - FFR • Can be done booth with S:t Jude (RADI) and Volcano pressure wire • Network to CoroNet monitoring system • Interface with V
Slide 3: Fractional Flow Reserve (FFR)
Accurate treatment in time Fractional Flow Reserve (FFR) Definition of FFR “Maximum achievable blood flow in stenotic coronary artery divided by Maximum blood flow in the same artery without stenosis” Pa (AO pressure via catheter) Pd (PressureWire) ___ Pd FFR = Pa At maximum hyperemia 3 Copyright ©
Slide 4: Fractional Flow Reserve (FFR)
Accurate treatment in time Fractional Flow Reserve (FFR) The reduction in myocardial blood flow by a stenosis, as indicated by FFR, can be closely correlated to Ischemia. FFR = 1.0 Normal artery FFR > 0.75 Ischemia very unlikely, sensitivity 88% FFR < 0.75 Ischemia, specificity 100% 4 Copyrigh
Slide 5: Conclusion
Accurate treatment in time Conclusion In this clinical example, FFR and PressureWire: • Confirmed the appropriateness of stenting the RCA while avoiding a risky intervention of the LAD/D1/D2 or bypass surgery • Selected the correct spots in the RCA where to place stents • Provided both the means for
Slide 6: The FAME trial
Accurate treatment in time The FAME trial (Fractional Flow Reserve versus Angiography in multivessel evaluation) 6 Copyright © 2009 Ortivus AB
Slide 7: The FAME trial
Accurate treatment in time The FAME trial Patient with lesions ≥ 50% in at least 2 of the 3 major epicardial vessels Indicate all lesions ≥ 50% amenable for stenting Randomization Angiography-guided PCI FFR-guided PCI Measure FFR in all arteries with ≥ 1 stenosis Stent all indicated stenoses Stent o
Slide 8: The FAME trial
Accurate treatment in time The FAME trial One year follow up results published in NEJM January 2009: • Routine FFR significantly improves outcomes after (DES) stenting in patients with multivessel disease (MVD) • FFR guided PCI reduces all types of events by 30% • FFR guided PCI lower costs without
Slide 9: The FAME trial
Accurate treatment in time The FAME trial ANGIO- FFR- group group P- value N=496 N=509 Death 15 (3.0%) 9 (1.8%) 0.19 Death or 55 (11.1%) 37 (7.3%) 0.04 myocardial infarction CABG or repeat PCI 47 (9.5%) 33 (6.5%) 0.08 Procedure time (min) 70 ± 44 71 ± 43 0.51 Contrast agent used 302 ± 127 272 ± 133
Slide 10: Why is FFR-guided PCI better than Image-guided?
Accurate treatment in time Why is FFR-guided PCI better than Image-guided? • Imaging modalities such as Angio, CT or IVUS can not identify which individual lesion is causing the patients ischemia. • Imaging modalities can both over- and under estimate lesion severity, either leaving significant lesi
Slide 11: Current standard for FFR measurement
Accurate treatment in time Current standard for FFR measurement PressureWire® AO - transducer Cathlab recording system 11 Copyright © 2009 Ortivus AB
Slide 12: Integrated FFR measurement
Accurate treatment in time Integrated FFR measurement PressureWire® Receiver PressureWire® Aeris AO - transducer Ortivus CoroNet PCI monitor with FFR software 12 Copyright © 2009 Ortivus AB
Slide 13: CoroNet PCI-monitor – FFR-measurement
Accurate treatment in time CoroNet PCI-monitor – FFR-measurement 13 Copyright © 2009 Ortivus AB