Ac Immune Sa · NASDAQ:ACIU

Ac Immune Sa — AD/PD 2022

12 slides from Ac Immune Sa's conference presentation, Mar 18, 2022

  1. Slide 1: Discovery of [18F]ACI-12589: A Novel and Promising PET-Tracer for Alpha-Synuclein

    DISCOVERY OF [18F]ACI-12589: A NOVEL AND PROMISING PET-TRACER FOR ALPHA-SYNUCLEIN Francesca Capotosti, PhD | AD/PD™ 2022 | 18 March

  2. Slide 2: Disclaimer

    Disclaimer This presentation contains statements that constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include s

  3. Slide 3: A-syn PET tracers can improve the diagnosis and treatment of NDD

    A-syn1 PET2 tracers can improve the diagnosis and treatment of NDD3 An effective PET tracer is needed to best enable precision medicine for a-synucleinopathies Early Diagnosis and Early diagnosis of a-syn-opathies4 is Benefits of PET tracers for imaging Treatment is Key in NDD not possible with curr

  4. Slide 4: Precision medicine approach enabled by the Morphomer platform

    Precision medicine approach enabled by the Morphomer® platform Developing a suite of PET1 tracers against emerging targets in NDD2 B C a-syn4 Lewy Tau NFTs3 TDP-435 inclusions bodies and neurites Leverage the Morphomer® small molecule platform: ▪ Non-peptidic, small molecules with CNS-drug propertie

  5. Slide 5: [3H]ACI-12589: a potential a-syn PET tracer

    ACI-12589: a potential a-syn1 PET2 tracer [3H]ACI-12589 specific binding on brain tissue from different a-synucleinopathy cases 3 4 Familial PD MSA Tissue slices Tissue homogenates Familial PD (nM) 150 binding (Frontal Cortex) Total Idiopathic PD MSA Specific binding Kd determination of ACI-12589 on

  6. Slide 6: [3H]ACI-12589 target engagement on different a-syn inclusions

    ACI-12589: a potential a-syn1 PET2 tracer [3H]ACI-12589 target engagement on a range of different a-syn inclusions PD3 (Amygdala) PDD4 (Amygdala) MSA5 (Caudate) DLB6 (Cingulate Gyrus) LBV7 (Amygdala) a-syn pS129 8 IHC Ref.: Capotosti et., AAIC 2020 20µm [3H]ACI-12589 (60nM) 20µm ■ ACI-12589 displays

  7. Slide 7: [18F]ACI-12589 specific binding on brain tissue from a-synucleinopathy cases

    ACI-12589: a potential a-syn1 PET2 tracer [18F]ACI-12589 specific binding on brain tissue from different a-synucleinopathy cases In collaboration with Prof. A. Varrone, Karolinska Institute Familial PD3 PDD4 PD5 MSA6 LBV7 Healthy Controls a-syn pS129 8 IHC binding Total Non-specific binding PD PD LB

  8. Slide 8: Selective versus Abeta and Tau

    ACI-12589: selective versus Abeta and Tau [3H]ACI-12589 assessed using Alzheimer’s disease tissue Radiobinding with AD1 brain homogenates High-resolution ARG2 on Tau rich AD sections 10000 (Frontal Cortex) (Entorhinal Cortex) 8000 Specific Binding (cpm) [3H]Abeta reference 6000 [3H]ACI-12589 Ref.: C

  9. Slide 9: Minimal off-target binding

    ACI-12589: minimal off-target binding [3H]ACI-12589 assessed for off-target binding to MAO-B1 Radiobinding on brain homogenates from healthy donor Autoradiography on MSA (Cerebellum) 120 (Thalamus) ACI-002620 ACI-17714 (Exp03) _ Deprenyl ACI-12589 ACI-012589 (1µM) (1µM) 100 [3H]ACI-12589 (10nM) THK-

  10. Slide 10: [18F]ACI-12589 as potential first-in-class PET tracer for MSA

    [18F]ACI-12589 as potential first-in-class PET1 tracer for MSA2 Representative PET scan images of MSA and controls In collaboration with Prof. O. Hanssosn, Skane University Hospital Cerebellar peduncle Cerebellar white matter ■ PET scan images suggest tracer retention in areas affected by disease pr

  11. Slide 11: [18F]ACI-12589 as potential first-in-class PET tracer for MSA: summary

    [18F]ACI-12589 as potential first-in-class PET1 tracer for MSA2 Data support the further clinical development in MSA, and continuing evaluation in other synucleinopathies Preclinical data Clinical data ▪ Significantly improved target binding with clean off-target profile ▪ Short scan time: good brai

  12. Slide 12: Acknowledgements

    Acknowledgements Efthymia Vokali Jerome Molette Myriam Ravache Christophe Delgado Jaqueline Kocher Laure Pittet Elpida Tsika Kasia Piorkowska Heiko Kroth Tanja Jürgens Ruth Luthi-Carter Valerie Hliva Olivier Sol Andrea Pfeifer Johannes Streffer Marie Kosco-Vilbois Oskar Hansson Ruben Smith Martin Sc

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