Brain Biotech Ag · XETR:BNN
Brain Biotech — Investor Day (December 2024)
27 slides from Brain Biotech's investor day presentation, Dec 12, 2024
Slide 1: BRAIN Biotech AG - BRAIN CMD 2024
BRAIN Biotech AG Creating a #BiobasedFuture BRAIN CMD 2024 Alexander Pelzer, VP Head of Research & Development Andrew Ellis, VP Fermentation & Technology Unique technology & production platform Zwingenberg, December 12th, 2024 Since 2021 we have been committed to the UN Global Compact corporate resp
Slide 2: Safe Harbor Statement
Safe Harbor Statement This document may contain forward-looking statements. These forward-looking statements are subject to risks and uncertainties, as they relate to future events and are based on current assumptions of the Company, which may not occur at all in the future or may not occur as assum
Slide 3: A Shared Technology Platform as the Engine of Business
A Shared Technology Platform as the Engine of Business the foundation of BRAINBiocatalysts' unique customer offering Creating a #BiobasedFuture © BRAIN Biotech AG Germany www.brain-biotech-group.com +49 (0) 6251-9331-0 3
Slide 4: Advanced Research & Development Platform
Advanced Research & Development Platform Tailor-made solutions from discovery to production Creating a #BiobasedFuture © BRAIN Biotech AG Germany www.brain-biotech-group.com +49 (0) 6251-9331-0 4
Slide 5: Research & Development Focus Areas Drive Innovation
Research & Development Focus Areas Drive Innovationg advanced technology portfolio designed to deliver Biosolutions Enzymes & Microorganisms & Bioprocesses & Proteins Production strains Scale-up Enzyme Technology Microbial Strain Development Bioprocess Development Enzyme discovery Bioprospecting Fer
Slide 6: Our inspiration
Our inspiration More than 3.5 billion years of innovative solutions in nature Creating a #BiobasedFuture © BRAIN Biotech AG Germany www.brain-biotech-group.com +49 (0) 6251-9331-0 6
Slide 7: The future is digital
The future is digital Nature is the role model. The methods are digital. Creating a #BiobasedFuture © BRAIN Biotech AG Germany www.brain-biotech-group.com +49 (0) 6251-9331-0 7
Slide 8: MetXtra – A Highly Sophisticated Technology Platform for New Enzymes
MetXtraTM – A Highly Sophisticated Technology Platform for New Enzymes streamlined process for the identification of novel enzymes for application database design Digitized biodiversity that continuously evolves Toolbox for AI generated enzymes 99.8 % of the protein sequences are novel Enzyme fine
Slide 9: Case study: Truly New Enzymes Discovered in MetXtra
Case study: Truly New Enzymes Discovered in MetXtraTM discovery of a proprietary CRISPR Cas-like genome editing tools Powerful tool for production strain development database Industrial enzyme production strains: • Escherichia coli • Bacillus subtilis • Komagataella phaffii (P. pastoris) discover •
Slide 10: Optimization of Enzymes for New & Improved Applications
Optimization of Enzymes for New & Improved Applications bioinformatics-guided approach for efficiently creating improved enzyme variants Reducing possibilities to what is beneficial Inherent options SSN ~ 20400 analysis Hot spot diversity MSA AI ~ 2050 diversity predictions Enzyme variants 100 Chara
Slide 11: Integration of Enzyme Discovery & Engineering Drives Success
Integration of Enzyme Discovery & Engineering Drives Success providing the best enzyme - regardless of the method ► Enzyme discovery & engineering are equally powerful tools for providing novel enzymes ► Having both available greatly increases the chances of success ► Integrated strategy to fuel enz
Slide 12: Industrial Enzyme Production Designed from Start to Finish
Industrial Enzyme Production Designed from Start to Finish end-to-end solution for enzymes ► Even the most exceptional enzymes must be producible at scale ► Powerful industrial production strains & bioprocesses are the door opener for commercial enzyme production New enzymes Plug & Produce Strain de
Slide 13: Development of Robust Industrial Production Strains & Processes
Development of Robust Industrial Production Strains & Processes an integrated platform for production strains & bioprocess development Industrial enzyme production strains Bioprocess development platform A. niger HE Plug & Produce: Process design & development: • Rapid testing of enzyme producibilit
Slide 14: Case Study: Integrated Platform for Strains & Bioprocess Development
Case Study: Integrated Platform for Strains & Bioprocess Development development of robust industrial production strains & processes ► Targeted & product-specific optimization to achieve high production yields New enzymes Plug & Produce Strain development Process development Manufacture Products Mon
Slide 15: Core Strengths of the Research & Development Platform
Core Strengths of the Research & Development Platform Highlights ► : Identification of unique, high-performance enzymes for industrial application ► Integrated enzyme discovery & engineering drive success in delivering novel enzymes ► High-yield industrial production strains ► Unique tools for produ
Slide 16: Contract Research Services – Range, Modularity & Flexibility
Contract Research Services – Range, Modularity & Flexibility Make it Special delivering tailor-made solutions across various industries Creating a #BiobasedFuture © BRAIN Biotech AG Germany www.brain-biotech-group.com +49 (0) 6251-9331-0 16
Slide 17: Fermentation Manufacturing Platform
Fermentation Manufacturing Platform From desktop to industrial scale Creating a #BiobasedFuture © BRAIN Biotech AG Germany www.brain-biotech-group.com +49 (0) 6251-9331-0 17
Slide 18: State-of-the-art Manufacturing Capabilities
State-of-the-art Manufacturing Capabilities perfectly suited to speciality enzymes Capabilities: • Pilot scale fermenters (≤ 750 L) • Manufacturing scale (2 x 10 m3) • Subcontractor network (15 - 50 m3) • Comprehensive down-stream processing • Sophisticated chromatography systems • Compatibility wit
Slide 19: Design-for-Manufacture Framework
Design-for-Manufacture Framework a key competitive differentiator for BRAINBiocatalysts New enzymes Plug & Produce Strain development Process development Manufacture Products Process Economics Sustainability Regulations Intellectual Property Quality Time Creating a #BiobasedFuture © BRAIN Biotech AG
Slide 20: Fermentation: Maximising Product Margins
Fermentation: Maximising Product Margins a critical success factor for driving EBITDA growth Capacity • Two fully functional 10 m3 fermenters with recent breakthroughs in increasing throughput 2023/24 productivity increase target: • Flexibility through an expanding range of EU fermentation partners
Slide 21: Core Strengths of the Fermentation Manufacturing Platform
Core Strengths of the Fermentation Manufacturing Platform Highlights ► State-of-the-art manufacturing capabilities utilizing 50L, 750L to 10 m3 to 50 m3 fermentation scale ► Extensive downstream processing and product purification options ► Design-for-manufacture framework maximises success ► A stro
Slide 22: Shared Technology Platform Drive Revenue Streams
Shared Technology Platform Drive Revenue Streams monetizing our R&D and fermentation capabilities ► Contract Research (Organization) Services (CRO) • Using the R&D platform to develop tailor-made biotech solutions for customers • Project revenues and license deals ► Contract Manufacturing (Organizat
Slide 23: Case Study: Hydrolase enzyme product [CRO/CMO]
Case Study Hydrolase enzyme product for production of a speciality carbohydrate [CRO/CMO] Customer need Development approach Results • A customer requirement for • Exclusivity and Enzyme discovery development of an enzyme commercialisation Enzyme identified from the MetXtraTM to modify a low-cost ag
Slide 24: Case Study: Lipase product [Product Development]
Case Study Lipase product for use in manufacture of a speciality food ingredient [Product Development] Market need Development approach Results • A market requirement for an Strain development • Lipase product launched to enzyme to modify a lipid Yeast strain developed for production of customers in
Slide 25: A Shared Technology Platform as the Business Engine
A Shared Technology Platform as the Business Engine the foundation of BRAINBiocatalysts unique customer offering Enzyme discovery & engineering Industrial production strains & strain engineering Bioprocess development & scale-up Extensive fermentation capability Enzyme product development Quality &
Slide 26: Thank you very much for your interest.
Thank you very much for your interest. BRAIN Biotech AG Darmstädter Straße 34−36 64673 Zwingenberg, Germany +49 (0) 6251-9331-0 www.brain-biotech-group.com Biocatalysts Ltd. Unit 1, Cefn Coed, Parc Nantgarw, Cardiff CF15 7QQ, Wales, UK +44 1443 843712 www.biocatalysts.com Your contacts: Alexander Pe
Slide 27: Case Study: Integrated Platform for Strains & Bioprocess Development
Case Study: Integrated Platform for Strains & Bioprocess Development development of robust industrial production strains & processes ► Targeted & product-specific optimization to achieve high production yields New enzymes Plug & Produce Strain development Process development Manufacture Products Mon