Twist Bioscience Corporation · NASDAQ:TWST
Twist Bioscience — Technical Presentation (June 2022)
24 slides from Twist Bioscience's technical presentation, Jun 1, 2022
Slide 1: Scaling up from Data Lakes to Data Oceans
Scaling up from Data Lakes to Data Oceans STEFFEN HELLMOLD 1 JUNE 2022
Slide 2: DNA Data Storage Market Opportunity
DNA Data Storage Market Opportunity 2
Slide 3: Data Creation & Storage Continues to Grow Exponentially
Data Creation & Storage Continues to Grow Exponentially Data created, replicated and consumed: Data storage worldwide capacity: 2021: 80 ZB 2025: 180 ZB 2021: 5 ZB 2025: 11 ZB PB ZB Source: IDC Global StorageSphere, 2021 3 | TWIST BIOSCIENCE
Slide 4: Challenges of Current Data Storage Technologies, Scaling et al.
Challenges of Current Data Storage Technologies, Scaling et al. • Increasing physical scaling challenges – Magnetic storage scaling is slowing down • Supply can’t keep up with demand – ZB-scale supply gap in 2nd half of this decade (Gartner) • Increasing demand for media diversity – Tape is the only
Slide 5: DNA Data Storage – Designing Storage Using Nature's Playbook
DNA Data Storage – Designing Storage Using Nature’s Playbook • The physics of DNA is well understood • Synthesis & sequencing technologies exists • DNA bases store bits: A, C, T, G 00, 10, 01, 11 • Enabling century scale archive storage solutions • Data is the Medium, Software Defined Storage • St
Slide 6: Storage Capacity No Issue for DNA Data Storage
Storage Capacity No Issue for DNA Data Storage 29,000x volumetric density 5,000,000x mass density >10x migration longevity Capacity: 20 TB Capacity: 18 TB Capacity: 250 μl By volume: 51.3 MB/mm3 By volume: 77.4 MB/mm3 By volume: ≈ 16.6 B/nm3 By weight: 29 GB/g By weight: 90 GB/g By weight: ≈ 450 EB/
Slide 7: DNA Data Storage Emerging as 'Time Capsule' Archive Storage
DNA Data Storage Emerging as ‘Time Capsule’ Archive Storage TODAY: MB-class Source: https://pdfs.semanticscholar.org/7b06/ba3effa9fc7b2f194a355bcb69601ef1ea56.pdf SOON: GB-class Early Access Solutions 7 | TWIST BIOSCIENCE
Slide 8: DNA Data Storage Technology
DNA Data Storage Technology 8
Slide 9: DNA Data Storage Workflow
DNA Data Storage Workflow 9 | TWIST BIOSCIENCE
Slide 10: Goal: Develop a Chip that Produces TB Scale Coded DNA
Goal: Develop a Chip that Produces TB Scale Coded DNA • DNA is synthesized on a chip – Use a 2D array of electrochemical reactors to synthesize strands of DNA – After synthesis, the DNA is washed into a tube, then amplified, purified, and packaged • Chip capacity is limited by the array pitch and ch
Slide 11: Packaging
Packaging Imagene’s DNASHELL • DNA degrades by oxidation – Hermetically packaging DNA leads to a long shelf life 7.5mm x 18mm – The package can be checked periodically for leaks – no leaks, no degradation • DNA is dense, but packaging needs to be practical – Industrial automation required for proces
Slide 12: Sequencing
Sequencing • Current sequencers focused on bio (genomics) applications • Practical for up to GB-class DNA Data Storage • Single run currently takes approximately 24 hours • Overall sequencing cost depends on reading frequency • As DNA sequencing cost is declining market will expand • Multiple groups
Slide 13: DNA Data Storage Productization
DNA Data Storage Productization 13
Slide 14: DNA Data Storage Solutions Concepts: Vault and Library
DNA Data Storage Solutions Concepts Vault Library • Offline / Offsite data archiving solution • Data Center ready solution • Air gapped / Hacker safe • Fully automated system with standard interface • Very low maintenance costs • Integrates with existing storage applications • High density / Small f
Slide 15: DNA Data Storage Solutions – Status
DNA Data Storage Solutions – Status Vault Library • Sampling today in MB scale • Requirements and design phase • GB scale pilots soon • Estimated availability in several years • TB scale will follow • Open for technology development collaboration • Currently only available for select pilot customers
Slide 16: DNA Data Storage – Library: Concept System Requirements
DNA Data Storage – Library: Concept System Requirements • System outline: – Granular storage: capsules / tray – Data maps logically to physical location – Standard data center environmental conditions – System components field serviceable / replaceable – Maximizes DNA volumetric storage density – Ma
Slide 17: DNA Data Storage – Key Technology Enablers
DNA Data Storage – Key Technology Enablers TB scale Synthesis TB per day Water-based PB scale Storage/Retrieval Automation Easy copy & store TB scale Sequencing TB per day Non-destructive Data Center Ready System Software integrated Object Storage APIs 17 | TWIST BIOSCIENCE
Slide 18: DNA Data Storage Customer Pilots
DNA Data Storage Customer Pilots 18
Slide 19: Twist DNA Data Storage Pilots
Twist DNA Data Storage Pilots • Archiving example use cases: – Movie series, videos, images, performances, ancient & important documents and manuscripts – Artwork, NFT art, crypto currency, scripts, museum collection, national anthem – Human race and individual legacy preservation 19 | TWIST BIOSCIE
Slide 20: DNA Data Storage Ecosystem
DNA Data Storage Ecosystem 20
Slide 21: Building the DNA Data Storage Ecosystem
Building the DNA Data Storage Ecosystem DNA Data Storage Alliance recently became a SNIA Technology Affiliate, with dedicated charter and P&P ● Formed in October 2020 by Ilumina, Microsoft, Twist and Western Digital History ● More than 50 member organizations across the entire eco system Mission ● C
Slide 22: DNA Data Storage Conclusion
DNA Data Storage Conclusion 22
Slide 23: DNA Data Storage – What it is and What it is not
DNA Data Storage – What it is and What it is not DNA is not… DNA is… • Storing all the world’s data in a shoebox • A new, complementary cold layer in the storage pyramid • Coming to a DC nearby in the next 2 years • An ideal medium for an offline copy and media diversity • A hot/warm storage medium
Slide 24: CARGATAGCGATGEACGAGEATEGACA
CARGATAGCGATGEACGAGEATEGACA GCTACGACTAGATAATETAGATGAGTA AGATGECGARGAGGGATTACTAGCATGATE 4 AGCACATTATCAGCGEGAATGCGCAGACEAEAGGACG GAGAGAGAGACGAATEGATECGAGETAGCTACGACTGAGTGGI ATATATGATARGGETTACTACGATCGACTACTARCAGERAGS \GBAGBGCGECGARGACGGATTACTAGCATGATEGATAGCTAG KAGECAGGATACTATCAGCG TTACAGCACTATEATCOGAGH
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