Evotec Se · XETR:EVT

Evotec — Fact Sheet (November 2024)

2 slides from Evotec's fact sheet, November 2024

1. Slide 1: Carboxylesterase (CE) Inhibition

   In vitro ADME & PK Carboxylesterase (CE) Inhibition Background Information Protocol • Human carboxylesterases (CE) are Test System Phase I drug metabolising enzymes of hCE1-b and/or hCE1-c expressed enzymes the serine hydrolase superfamily. They hydrolyse a variety of ester containing drugs Substrat

2. Slide 2: Inhibition of trandolapril metabolism in recombinant hCE1-b by benzil

   ‘modulation of CE activity may present an opportunty to alter drug metabolism and pharmacokinetics, with the ultimate goal of improving therapy.’1 Figure 1 Inhibition of trandolapril (hCE1 substrate) metabolism in recombinant hCE1-b by benzil. References 1 Hatfield M.J. and Potter P.M. (2011) Expert

Evotec — Fact Sheet (November 2024) on 6ix