Altria Group, Inc. · NYSE:MO
Altria — 2022 FDLI Annual Conference
6 slides from Altria's conference presentation, Jun 19, 2022
Slide 1: Demonstrating "Appropriate for the Protection of Public Health" (APPH)
Demonstrating “Appropriate for the Protection of Public Health” (APPH) Jason W. Flora, Ph.D. Associate Fellow Altria Client Services Regulatory Affairs 2022 FDLI Annual Conference I Access materials at fdli.org/annual2022
Slide 2: Risk Cliff Between Combustible & Smoke-free Tobacco
Risk Cliff Between Combustible & Smoke-free Tobacco Adapted from Nutt, et. al Estimating the Harms of Nicotine-Containing Products Using the MCDA Approach. Eur. Addict Res 2014; 20:218-225. 2022 FDLI Annual Conference I Access materials at fdli.org/annual2022
Slide 3: Scientific Framework for Evaluating Reduced-Harm Tobacco Products
Scientific Framework for Evaluating Reduced-Harm Tobacco Products CONSTITUENT INDIVIDUAL RISK POPULATION HARM REDUCTION REDUCTION REDUCTION Risks and Product Chemical Toxicology Studies in Perception Benefits to Design and and Physical and Risk Adult Human and Behavior Health of the Control Characte
Slide 4: Recent PMTA: Oral Tobacco Derived Nicotine Products (OTDN)
Recent PMTA: Oral Tobacco Derived Nicotine Products (OTDN) • On May 15th, 2020, we submitted PMTAs for a portfolio of OTDN products • The products, on!® Nicotine Pouches are tobacco leaf-free and only contain pharmaceutical grade tobacco-derived nicotine and non-tobacco ingredients • Many of the ing
Slide 5: Integration of Multiple Lines of Evidence to Demonstrate on!® Nicotine Pouches are APPH
Integration of Multiple Lines of Evidence to Demonstrate that on!® Nicotine Pouches are APPH* HPHC reduced / eliminated Switching completely will substantially reduce exposure to most HPHCs which should reduce smoking related disease risks Abuse potential lower or comparable to cigarettes or ST Adul
Slide 6: Accelerating APPH Determinations for Reduced Risk Products
Accelerating APPH Determinations for Reduced Risk Products Products Standards Accelerated review times Viable pathway(s) for for supplemental PMTAs minor product changes 2022 FDLI Annual Conference I Access materials at fdli.org/annual2022