Altria Group, Inc. · NYSE:MO
Altria — CORESTA 2018
21 slides from Altria's conference presentation, October 2018
Slide 1: Characterization of Puff Topography of Adult Conventional Cigarette Smokers and Exclusive e-Vapor Users
Characterization of Puff Topography of Adult Conventional Cigarette Smokers and Exclusive e-Vapor Users During Ad Libitum use of MarkTen® e-Vapor Products Jeff Edmiston, Andrea Vansickel, Qiwei Liang, Maria Gogova, Mohamadi Sarkar, George Karles Altria Client Services l Edmiston l Oct. 22-26 l CORES
Slide 2: Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems
Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems DRAFT GUIDANCE – May 2016 “Assessment of user topography (how individual users consume the product, e.g., the number of puffs, puff duration, puff intensity, duration of use), the frequency with which consumers use the p
Slide 3: E-Vapor Products (all unbranded)
E-Vapor Products (all unbranded) Group 1: Non-Menthol Test Products • Bold Classic: XL40CB [4.0% nicotine by weight] • Fusion: XL25F [2.5% nicotine by weight] • Classic: XL35C [3.5% nicotine by weight] Group 2: Menthol Test Products • Bold Menthol: XL40MB [4.0% nicotine by weight] • Winter Mint: XL3
Slide 4: SODIM Puff Analyzer Mobile
SODIM Puff Analyzer Mobile MarkTen® Mouthpiece Adaptor • 3 pressure sensors (two measure differences at mouthpiece, 1 atmospheric) • 50 millisecond recording • Analyzed with SODafc software Altria Client Services l Edmiston l Oct. 22-26 l CORESTA 2018 l 4
Slide 5: Study Purpose
Study Purpose To characterize the puff topography (puff count, puff duration, puff volume) when using MarkTen® XL in: • Adult cigarette smokers on Day 1 and after 1 week of use No e-vapor products in the past 30 days • Adult e-vapor users on Day 1 and after 1 week of use Minimum of 6 months and
Slide 6: Study Conduct
Study Conduct 60 min break N=121 61 Cigarette Smokers (CS) 60 e-Vapor Users (EV) Product CS XL35C XL35C XL35C Trial N=30 XL25F XL25F XL25F Group 1: or or or EV 1 week Non- XL40CB XL40CB XL40CB Eligibility Menthol N=30 with last and Safety product Screening Product CS XL35M XL35M XL35M used on N=31 X
Slide 7: Group 1
Group 1 Altria Client Services l Edmiston l Oct. 22-26 l CORESTA 2018 l 7
Slide 8: Group 1: Study Participant Demographics
Group 1: Study Participant Demographics Cigarette Smokers e-Vapor Users Total (N=30) (N=30) (N=60) Age (years) Mean 40.1 39.4 39.8 SD 11.2 11.9 11.5 Sex Male 13 18 31 43.3% 60.0% 51.7% Female 17 12 29 56.7% 40.0% 48.3% Race Black 16 4 20 53.3% 13.3% 33.3% White 11 21 32 36.7% 70.0% 53.3% Other 3 5 8
Slide 9: Group 1: Tobacco Use History
Group 1: Tobacco Use History Cigarette Smokers: e-Vapor Users: Years Smoking 15 (+/- 9) Years e-Vapor Use 1.9 (+/-1.6) Cigarettes Per Day 14.8 (+/-4.1) Type of e-Vapor: • Disposable / Rechargeable 8 (26.7%) • e-Liquid Refillable 22 (73.3%) Altria Client Services l Edmiston l Oct. 22-26 l CORESTA 201
Slide 10: Group 1: Average Puff Counts Over Minutes
Group 1: Average Puff Counts Over 90 Minutes Cigarette Smokers e-Vapor Users Puff Number (+/-95%CI) Bold Classic Fusion Classic Effect P value Smokers vs. e-Vapor Users 0.6917 Day 1 vs. Day 8 <0.0001 Smokers or e-Vapor Users vs. Products 0.8565 linear mixed model for analysis of variance Altria Clie
Slide 11: Group 1: Average Puff Duration
Group 1: Average Puff Duration Cigarette Smokers e-Vapor Users Puff Duration (s) (+/-95%CI) Bold Classic Fusion Classic Effect P value Smokers vs. e-Vapor Users <0.0001 Day 1 vs. Day 8 <0.0001 Smokers or e-Vapor Users vs. Products 0.2954 linear mixed model for analysis of variance Altria Client Serv
Slide 12: Group 1: Average Puff Volume
Group 1: Average Puff Volume Cigarette Smokers e-Vapor Users Puff Volume (ml) (+/-95%CI) Bold Classic Fusion Classic Effect P value Smokers vs. e-Vapor Users 0.0727 Day 1 vs. Day 8 0.6004 Smokers or e-Vapor Users vs. Products 0.2910 linear mixed model for analysis of variance Altria Client Services
Slide 13: Group 2
Group 2 Altria Client Services l Edmiston l Oct. 22-26 l CORESTA 2018 l 13
Slide 14: Group 2: Study Participant Demographics
Group 2: Study Participant Demographics Cigarette Smokers e-Vapor Users Total (N=31) (N=30) (N=61) Age (years) Mean 37.8 40.4 39.1 SD 11.5 12.4 12 Sex Male 14 18 32 45.20% 60.00% 52.50% Female 17 12 29 54.80% 40.00% 47.50% Race Black 24 17 41 77.40% 56.70% 67.20% White 4 12 16 12.90% 40.00% 26.20% O
Slide 15: Group 2: Tobacco Use History
Group 2: Tobacco Use History Cigarette Smokers: e-Vapor Users: Years Smoking 14.6 (+/- 11) Years e-Vapor Use 2.2 (+/-2.1) Cigarettes Per Day 13.6 (+/-4.7) Type of e-Vapor: • Disposable / Rechargeable 9 (30.0%) • e-Liquid Refillable 21* (70.0%) *4 subjects reported using multiple types of products Al
Slide 16: Group 2: Average Puff Counts Over Minutes
Group 2: Average Puff Counts Over 90 Minutes Cigarette Smokers e-Vapor Users Puff Number (+/-95%CI) Bold Menthol Winter Mint Menthol Effect P value Smokers vs. e-Vapor Users 0.8728 Day 1 vs. Day 8 0.0026 Smokers or e-Vapor Users vs. Products 0.5328 linear mixed model for analysis of variance Altria
Slide 17: Group 2: Average Puff Duration
Group 2: Average Puff Duration Cigarette Smokers e-Vapor Users Puff Duration (s) (+/-95%CI) Bold Menthol Winter Mint Menthol Effect P value Smokers vs. e-Vapor Users 0.0483 Day 1 vs. Day 8 <0.0001 Smokers or e-Vapor Users vs. Products 0.7198 linear mixed model for analysis of variance Altria Client
Slide 18: Group 2: Average Puff Volume
Group 2: Average Puff Volume Cigarette Smokers e-Vapor Users Puff Volume (ml) (+/-95%CI) Bold Menthol Winter Mint Menthol Effect P value Smokers vs. e-Vapor Users 0.2608 Day 1 vs. Day 8 0.0006 Smokers or e-Vapor Users vs. Products 0.7323 linear mixed model for analysis of variance Altria Client Serv
Slide 19: Overall Average: Day 1 and Day 8
Groups 1 and 2 Overall Average: Day 1 and Day 8 Puff Volume (ml) (+/-95%CI) Puff Duration (s) (+/-95%CI) Puff Number (+/-95%CI) Cartridge Changes (mg) (+/-95%CI) Although participants took fewer puffs on Day 8, they increased their puff duration and maintained the same level of e-Liquid use Data fro
Slide 20: Summary and Conclusions
Summary and Conclusions • Within each Group, cigarette smokers used the different MarkTen® products similarly • Within each Group, e-Vapor users used the different MarkTen® products similarly • In general, e-Vapor users took longer puffs than cigarette smokers • After 1 week acclimation to the produ
Slide 21: For copies of this presentation visit Altria's Science Website
For copies of this presentation visit the Altria’s Science Website at www.altria.com/alcs-science Altria Client Services l Edmiston l Oct. 22-26 l CORESTA 2018 l 21