Neurizon Therapeutics Limited · ASX:NUZ
Neurizon Therapeutics — PharmAust — ANZCVS Annual Scientific Conference "Science Week" 2022
6 slides from Neurizon Therapeutics's conference presentation, Jun 24, 2022
Slide 1: Science Week Conference Presentation
Science Week Conference Presentation 24 June 2022 – Perth, Australia: PharmAust Limited (ASX: PAA & PAAO), a clinical-stage biotechnology company is pleased to provide the enclosed presentation which will be presented tomorrow by Dr Catherine Chan BVSc (Hons I) FANZCVS (Onc) DACVIM (Onc), at the Aus
Slide 2: MPL clinical trial – what's happening? Common Cancer in Dogs
MPL clinical Common trialCancer – what’s in happening? Dogs • Oral anti-cancer tablet administered once daily • MOA – appears to act as mTOR inhibitor • Safe in healthy, tumour bearing & lymphoma dogs • Main side effects at ‘high doses’ = GI (anorexia, weight loss) + mild hepatopathy (ALP > ALT) • P
Slide 3: Phase II clinical trial in dogs for B-cell lymphoma
Phase IICommon Cancer clinical trial in Dogs for B-cell lymphoma • Stage I • 15 dogs • 3 different doses • Duration = 28 days • Minimal change in body weight ± 2% • Clinical benefit = 40% (1 PR, 5 SD, 9 PD) • Post trial analysis on 8 dogs • MPL for 28-days à MPL + prednisolone • MST = 144 days (~5 m
Slide 4: Dogs eligible for the study
Dogs Common eligible Cancer for the in Dogs study • Eligibility: • Naïve B-cell lymphoma – cytology or histologic diagnosis (IHC can be pending) • Weight ≥ 8 kg • Modified Karnofsky performance score 0 or 1 (acceptably functional pet) • No other significant diseases • Life expectancy >4 weeks • No p
Slide 5: Monitoring schedule in the canine cancer trial
Common Monitoring Cancer in Dogs Day -7 to 0 0 14 28 Physical examination (and response assessment) x ($ not covered) x x x Owner log review x x x (explanation) CBC including smear review (pathologist) x x x *If no other Serum chemistry x x x exclusion Urinalysis including sediment examination x x x
Slide 6: Study Sites
Common Study Cancer Sitesin Dogs U-Vet, Melbourne (Stage 1 only) VSA, Auckland UVTHS, Sydney (Stage 1 only) Heart of Texas, USA ARH, Sydney WAVES, Perth PVS, Perth ARH, Brisbane VSS, Brisbane
PharmAust — ANZCVS Annual Scientific Conference "Science Week" 2022 on 6ix